Control of hepatitis B through routine immunization of infants: the need for flexible schedules and new combination vaccine formulations

Vaccine
D J WestW J Miller

Abstract

Universal immunization of infants is essential to the control of hepatitis B in areas of high endemicity where infection commonly occurs in infants and children. It is also an attractive strategy for ultimately reducing hepatitis-B-associated acute and chronic liver disease in areas of lower endemicity where infections occur primarily in adolescents and adults. Integration of hepatitis B vaccine with other routine paediatric immunizations, using flexible scheduling, will enhance compliance while minimizing the need for additional resources. Clinical studies demonstrate that a very high proportion of healthy infants and adults develop a protective level of antibody when given hepatitis B vaccine using a wide range of schedules. Compliance with universal vaccination of infants against hepatitis B may be enhanced by the development of new combination vaccines (e.g. diphtheria-tetanus-pertussis-Haemophilus influenzae b-hepatitis B) that allow complete immunization against several antigens with a minimal number of injections.

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Citations

Jan 22, 2005·BMJ : British Medical Journal·Osman David Mansoor, Nick Wilson
Feb 7, 2007·Expert Review of Vaccines·Osman David Mansoor, Peter Salama
Sep 24, 2005·Pediatric Transplantation·Andrew L Campbell, Betsy C Herold
Apr 23, 2009·The Pediatric Infectious Disease Journal·Sharon H WongDiana R Martin
Feb 1, 2007·Indian Journal of Pediatrics·Sonia PuriAmrit Kaur
Aug 5, 2008·The Cochrane Database of Systematic Reviews·Joseph L MathewJesper Brok
Apr 9, 1999·Clinical Microbiology Reviews·F J Mahoney

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