Control of hierarchical polymer mechanics with bioinspired metal-coordination dynamics

Nature Materials
Scott C GrindyNiels Holten-Andersen

Abstract

In conventional polymer materials, mechanical performance is traditionally engineered via material structure, using motifs such as polymer molecular weight, polymer branching, or block copolymer design. Here, by means of a model system of 4-arm poly(ethylene glycol) hydrogels crosslinked with multiple, kinetically distinct dynamic metal-ligand coordinate complexes, we show that polymer materials with decoupled spatial structure and mechanical performance can be designed. By tuning the relative concentration of two types of metal-ligand crosslinks, we demonstrate control over the material's mechanical hierarchy of energy-dissipating modes under dynamic mechanical loading, and therefore the ability to engineer a priori the viscoelastic properties of these materials by controlling the types of crosslinks rather than by modifying the polymer itself. This strategy to decouple material mechanics from structure is general and may inform the design of soft materials for use in complex mechanical environments. Three examples that demonstrate this are provided.

References

Dec 11, 2003·Journal of the American Chemical Society·Wayne C YountStephen L Craig
Jul 15, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Mary J Sever, Jonathan J Wilker
Aug 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Haeshin LeePhillip B Messersmith
Jul 10, 2007·Nature Materials·Niels Holten-AndersenFrank W Zok
Aug 19, 2007·Biomaterials·Jindrich Kopecek
Mar 6, 2010·Science·Matthew J HarringtonPeter Fratzl
Feb 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Niels Holten-AndersenJ Herbert Waite
Sep 8, 2012·Nature·Jeong-Yun SunZhigang Suo
Feb 27, 2013·Macromolecules·Dominic E FullenkampPhillip B Messersmith
Oct 17, 2013·ACS Applied Materials & Interfaces·Can Hui YangZhigang Suo
Nov 15, 2013·Advanced Materials·Julian ThieleWilhelm T S Huck
Oct 29, 2014·Journal of the American Chemical Society·Davoud MozhdehiZhibin Guan
May 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Niels Holten-AndersenKa Yee C Lee

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Citations

May 25, 2016·Nature Chemistry·Cheng-Hui LiZhenan Bao
Aug 9, 2016·Journal of the American Chemical Society·Manish NepalJean Chmielewski
Nov 1, 2016·Nature Nanotechnology·Junling GuoFrank Caruso
Nov 2, 2016·ACS Applied Materials & Interfaces·Fengbo ZhuQiang Zheng
Mar 3, 2017·ACS Applied Materials & Interfaces·Jie ZhanZhimou Yang
Oct 22, 2016·Angewandte Chemie·Md Arifur RahimFrank Caruso
Jun 29, 2017·Journal of the American Chemical Society·B Kollbe Ahn
Jul 1, 2017·Journal of the American Chemical Society·Eric A AppelOren A Scherman
Sep 8, 2017·Chemistry : a European Journal·Ning ZhouBing Xu
Oct 28, 2017·Science·Emmanouela FilippidiMegan T Valentine
Jan 23, 2018·Advanced Materials·Anton H HofmanMarleen Kamperman
May 22, 2018·Soft Matter·German Alberto Parada, Xuanhe Zhao
Nov 23, 2017·Biomaterials Science·Joseph L MannEric A Appel
May 24, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kun XueXian Jun Loh
Aug 24, 2017·Advanced Materials·Sungbaek SeoB Kollbe Ahn
Sep 18, 2018·Angewandte Chemie·Md Arifur RahimFrank Caruso
Dec 1, 2018·Nanoscale·Isabell TunnMatthew J Harrington
Sep 5, 2017·Nature·Mohammad Vatankhah-VarnosfaderaniSergei S Sheiko
May 16, 2019·Chemistry : a European Journal·Longyu LiChenfeng Ke
Sep 19, 2016·Bioengineering & Translational Medicine·Matthew J Webber
Dec 28, 2019·Macromolecular Rapid Communications·Xiaomin TangChristopher J Bettinger
Jul 17, 2019·Angewandte Chemie·Yuwei GuJeremiah A Johnson
Sep 10, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T-M FungA M Smith
Jun 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinfeng CaoJinping Zhou
Nov 16, 2019·Angewandte Chemie·Margarita Vázquez-González, Itamar Willner
Aug 16, 2016·Advanced Materials·Seonki HongRalph Weissleder
Dec 6, 2016·Journal of Polymer Science. Part A, Polymer Chemistry·Pegah Kord Forooshani, Bruce P Lee
Apr 5, 2017·Macromolecular Rapid Communications·Heqin HuangKai Zhang
Nov 23, 2017·The Journal of Chemical Physics·Michelle K SingBradley D Olsen
Mar 31, 2018·Science·Mohammad Vatankhah-VarnosfaderaniSergei S Sheiko
Nov 9, 2019·Chemical Science·Mattias BjörnmalmMolly M Stevens
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Boguang YangLiming Bian

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Methods Mentioned

BETA
NMR
rheology

Software Mentioned

matlab

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