Control of human luteal steroidogenesis: role of growth hormone-releasing hormone, vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide

Fertility and Sterility
R ApaS Mancuso

Abstract

To examine the possible effect of growth hormone-releasing hormone (GHRH), vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide on basal and hCG-stimulated P production by human luteal cells. Cultures of human luteal cells from the early and midluteal phase. All corpora lutea were obtained from the Obstetrics and Gynecology Department of the Università Cattolica, a public care center. Ten nonpregnant women between 35 and 47 years of age underwent surgery for various nonendocrine disorders, such as leiomyomatosis. Corpora lutea were obtained at the time of hysterectomy. Luteal cells were incubated with GHRH, vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide with or without hCG at different concentrations. Pituitary adenylate cyclase-activating peptide stimulated P production in a dose- and time-dependent manner, whereas GHRH and vasoactive intestinal peptide did not affect luteal steroidogenesis. None of the three peptides were found to synergize with hCG. Pituitary adenylate cyclase-activating peptide can influence human luteal steroidogenesis.

References

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Citations

Oct 20, 1999·Domestic Animal Endocrinology·D R Deaver, K A Bryan
Nov 15, 2002·Trends in Endocrinology and Metabolism : TEM·Costanzo MorettiGaetano Frajese
Oct 20, 2007·Molecular and Cellular Endocrinology·Emma R Isaac, Nancy M Sherwood
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Jul 18, 2001·Microscopy Research and Technique·L YonH Vaudry
Oct 3, 2012·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Marisa AgneseMarina Prisco

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