Control of Immunity by the Microbiota.

Annual Review of Immunology
Eduard AnsaldoYasmine Belkaid


The immune system has coevolved with extensive microbial communities living on barrier sites that are collectively known as the microbiota. It is increasingly clear that microbial antigens and metabolites engage in a constant dialogue with the immune system, leading to microbiota-specific immune responses that occur in the absence of inflammation. This form of homeostatic immunity encompasses many arms of immunity, including B cell responses, innate-like T cells, and conventional T helper and T regulatory responses. In this review we summarize known examples of innate-like T cell and adaptive immunity to the microbiota, focusing on fundamental aspects of commensal immune recognition across different barrier sites. Furthermore, we explore how this cross talk is established during development, emphasizing critical temporal windows that establish long-term immune function. Finally, we highlight how dysregulation of immunity to the microbiota can lead to inflammation and disease, and we pinpoint outstanding questions and controversies regarding immune system-microbiota interactions.


Jan 1, 1989·The Journal of Investigative Dermatology·D MetzeG Niebauer
Mar 1, 1996·Gut·L A van der WaaijD van der Waaij
Aug 3, 2002·Nature Immunology·Mikhail B LitinskiyAndrea Cerutti
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yaping ChenRichard Boismenu
Jan 8, 2003·The Journal of Experimental Medicine·Kevin J MaloyFiona Powrie
Mar 3, 2004·Obstetrics and Gynecology·Michael V ZaretskyRoger E Bawdon
Jun 7, 2005·The Journal of Clinical Investigation·Daniel MucidaMaria A Curotto de Lafaille
Oct 13, 2006·The Journal of Experimental Medicine·Marika C KullbergAlan Sher
Oct 13, 2006·The Journal of Experimental Medicine·Sophie HueKevin J Maloy
Nov 18, 2006·Science·J Rodrigo MoraUlrich H von Andrian
Aug 19, 2007·Nature Reviews. Immunology·Derry C Roopenian, Shreeram Akilesh
Nov 17, 2007·Cell Host & Microbe·Daniel A PetersonJeffrey I Gordon
Mar 29, 2008·Annual Review of Immunology·Troy D RandallJavier Rangel-Moreno
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper
Sep 13, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Julia B EwaschukKaren L Madsen
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anisa S IsmailLora V Hooper
Apr 8, 2009·The Journal of Clinical Investigation·Edward E S NieuwenhuisRichard S Blumberg
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yingzi CongCharles O Elson
Jan 27, 2010·Journal of Clinical Immunology·Leman Yel
Mar 3, 2010·Annual Review of Immunology·Sidonia FagarasanKeiichiro Suzuki
Apr 24, 2010·Journal of Autism and Developmental Disorders·Hjördis O AtladóttirErik T Parner
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maria G Dominguez-BelloRob Knight

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