Abstract
In an attempt to encourage more intensive studies on the control of immunologic abnormalities associated with aging, the six different approaches which have been attempted are reviewed briefly. They are as follows: (a) internal body temperature control, (b) tissue ablation, (c) dietary manipulation, (d) genetic manipulation, (d) genetic manipulation (e) cell therapy and (f) chemical therapy. The first four are preventive and the latter two are restorative in approach. Many of these studies are very preliminary, but overall, the findings are most encouraging. These studies should resolve the extent to which decline in immunologic vigor with age influences the disease pattern of aging individuals and on their life expectancy.
References
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R G Cutler
Mar 1, 1977·Mechanisms of Ageing and Development·G E Bilder, W D Denckla
Nov 2, 1976·The Journal of Experimental Medicine·J W Albright, T Makinodan
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·G FernandesR A Good
Jan 9, 1975·The New England Journal of Medicine·D W WaraA J Ammann
Feb 28, 1975·Annals of the New York Academy of Sciences·N TalalR Goldblum
Mar 1, 1975·Journal of Gerontology·R K Liu, R L Walford
Jan 1, 1973·International Archives of Allergy and Applied Immunology·G FernandesR A Good
Jan 11, 1969·Lancet·D MazzeiV Simonati
Jan 25, 1974·Prostaglandins·M JohnsonP W Ramwell
Dec 1, 1969·Experimental Gerontology·J F AlbrightJ W Deitchman
Oct 1, 1971·Journal of Gerontology·F ChinoW J Peterson
Dec 29, 1972·Nature·N FabrisE Sorkin
Dec 1, 1973·Mechanisms of Ageing and Development·R L WalfordG S Smith
Mar 1, 1968·Biochemical Pharmacology·E V Barnett
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·G FernandesR A Good
Apr 30, 1971·Annals of the New York Academy of Sciences·W LandsW Smith
Jun 1, 1966·Journal of Cellular Physiology·J F Albright, T Makinodan
Jan 15, 1967·International Journal of Cancer. Journal International Du Cancer·D Metcalf, R Moulds
Feb 1, 1974·The Journal of Clinical Investigation·W D Denckla
Feb 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·T MAKINODAN, W J PETERSON
Jan 1, 1946·Journal of Gerontology·J FURTH
Citations
Nov 1, 1992·Annals of Hematology·H EverausH Kŏdar
Jul 1, 1983·Journal of Steroid Biochemistry·C J Grossman, G A Roselle
Aug 1, 1983·Journal of the Neurological Sciences·I AlafuzoffB Winblad
Feb 1, 1985·Journal of the Neurological Sciences·A LeonardiR Vecchia
Jun 1, 1979·Mechanisms of Ageing and Development·T Makinodan, J W Albright
Aug 1, 1979·Mechanisms of Ageing and Development·T Makinodan, J W Albright
Jun 1, 1980·Mechanisms of Ageing and Development·W E MüllerN Munsch
Jan 1, 1980·Mechanisms of Ageing and Development·M L HeidrickT Makinodan
Mar 1, 1981·Clinics in Endocrinology and Metabolism·M Green
Jan 1, 1983·Journal of Chronic Diseases·K W Walton
Feb 1, 1997·Immunopharmacology and Immunotoxicology·V G VillarrubiaM Alvarez-Mon
May 31, 2014·Journal of Food Science and Technology·Deepti Kaushal, Vinod K Kansal
May 1, 1986·Veterinary Pathology·C F KuperV M Hollanders