Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides

Journal of Controlled Release : Official Journal of the Controlled Release Society
Akira MakinoShunsaku Kimura

Abstract

Polymeric micelle, "Lactosome", is composed of amphiphilic polydepsipeptide with a hydrophobic block of helical poly(L-lactic acid) (PLLA) and a hydrophilic block of poly(sarcosine). Lactosome was labeled by incorporation of poly(lactic acid) having a near-infrared fluorescence (NIRF) chromophore, and studied on blood clearance and tumor imaging. In vivo blood clearance time of Lactosome was prolonged with incorporation of poly(D-lactic acid) (PDLA), but decreased with poly(D,L-lactic acid) (PDLLA). NIRF imaging with applying these Lactosomes to tumor-bearing mice revealed that the tumor/background intensity ratio increased with incorporation of PDLLA. Stereochemistry in the hydrophobic core of self-assemblies is thus an important factor for determining physical stability in the blood stream and consequently contrast in imaging.

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Jan 1, 2008·Bioconjugate Chemistry·Hiroki TanisakaShunsaku Kimura
Jul 8, 2008·Macromolecular Bioscience·Tatsuya KanzakiShunsaku Kimura
Mar 10, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuanpei LiKit S Lam
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Citations

Nov 8, 2014·TheScientificWorldJournal·Akira Makino, Shunsaku Kimura
Jul 28, 2016·Chemistry of Materials : a Publication of the American Chemical Society·Sunting XuanDonghui Zhang
Dec 25, 2015·Chemical Reviews·Niklas GangloffRobert Luxenhofer
Mar 9, 2017·Molecular Pharmaceutics·Hoda Soleymani AbyanehAfsaneh Lavasanifar
Sep 15, 2016·Bioorganic & Medicinal Chemistry Letters·Masashi OhmaeShunsaku Kimura
Nov 8, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Cheol Joo KimShunsaku Kimura
May 1, 2014·Biomaterials Science·King Hang Aaron Lau
Nov 24, 2016·Science and Technology of Advanced Materials·Akiya AkahoshiTakashi Ohtsuki
Jan 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Saide CuiKai Guo
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maksim Nikulin, Vytas Švedas

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