Control of influenza infection is impaired by diminished interferon-γ secretion by CD4 T cells in the lungs of toddler mice

Journal of Leukocyte Biology
David VerhoevenKarin Pryharski

Abstract

Respiratory viral infections, such as influenza, can lead to delayed viral clearance in toddlers, possibly exacerbating disease morbidity. We hypothesized that defective CD4 T cells in toddlers may contribute to a failure to clear virus at a similar rate to adults. Thus, we developed a young mouse model to examine potential divergent responses between toddlers and adults. We determined that young mice (toddler mice, 21 d old) were actively generating and recruiting effector/memory T cells, whereas memory populations were firmly established in older, adult mice (8-10 wk old). We infected toddler and adult mice with influenza A/PR8/34 (H1N1) and found young mice had elevated morbidity, as measured by enhanced weight loss and lower partial pressure of oxygen levels, throughout the infection, thus, modeling the higher morbidity observed in children (<2 y old) during infection. Early viral loads were comparable to adult mice, but toddler mice failed to clear virus by 10 d postinfection. This delayed clearance corresponded to poor lung recruitment of CD4 T cells, lower antiviral T cell responses, and lower B cell/antibodies in the lungs. Mechanistically, diminished interferon-γ was detected in the lungs of toddler mice throughout the...Continue Reading

References

Aug 1, 1976·Journal of Clinical Pathology·A J Al BarzanjiJ L Emery
Jan 1, 1989·Scandinavian Journal of Immunology·J Westerga, W Timens
May 12, 2001·Vaccine·C A Siegrist
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K A BentonS L Epstein
Jan 25, 2002·The Journal of Infectious Diseases·Kathleen M NeuzilPeter F Wright
Mar 31, 2004·The Journal of Experimental Medicine·Stanislas GorielyMichel Goldman
Aug 17, 2004·Vaccine·Takuji KumagaiHitoshi Kamiya
Sep 16, 2004·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arun T KamathDavid F Tough
Jun 4, 2005·Blood·Thierry WalzerEric Vivier
Oct 3, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Paula A VelillaClaire A Chougnet
Nov 23, 2006·The Medical Journal of Australia·Mark BoydRod Pearce
Mar 7, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Hai Lee ChungSang Gyung Kim
Jun 15, 2007·Journal of Comparative Pathology·C-A Siegrist
Sep 3, 2008·The Journal of Experimental Medicine·Hyun-Hee LeeHabib Zaghouani
Feb 26, 2009·Nature Reviews. Immunology·Claire-Anne Siegrist, Richard Aspinall
Apr 8, 2009·Expert Review of Vaccines·Arnold S Monto, Suzanne E Ohmit
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·John R TeijaroDonna L Farber
Jul 29, 2009·European Journal of Immunology·Joelle RennesonArnaud Marchant
Oct 23, 2009·Trends in Immunology·Habib ZaghouaniBecky Adkins
Nov 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Smita S ChandranDonna L Farber
Jan 13, 2010·Clinical Microbiology Reviews·John S Tregoning, Jürgen Schwarze
Mar 23, 2010·Pathologie-biologie·B CombadièreD Duffy
Jul 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Louise LinesBeth A Garvy
Nov 17, 2011·Nucleic Acids Research·Xiaowei WangBrian Seed
Mar 17, 2012·Scandinavian Journal of Immunology·E J H SchatorjéE de Vries
Sep 25, 2012·The Journal of Infectious Diseases·Chad M CoxUNKNOWN Emerging Infections Programs Network
Dec 12, 2012·Scandinavian Journal of Immunology·A K LidehällB-M Eriksson
Sep 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael A JhungLyn Finelli
Jun 19, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca E RiiseFredrik B Thorén
Jun 14, 2016·Journal of Thoracic Disease·Sai-Bo PanYing Chai

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Citations

Oct 17, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Luciana P TavaresCristiana C Garcia
Jul 2, 2020·American Journal of Respiratory Cell and Molecular Biology·Andrew D PriggeKaren M Ridge
Oct 28, 2019·Molecular Therapy Oncolytics·Brian HutzenKevin A Cassady

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