PMID: 2509620Oct 1, 1989Paper

Control of inhibin production by primate granulosa cells

The Journal of Endocrinology
S G HillierA S McNeilly

Abstract

In-vitro data from experiments on rats implicate granulosa cells as primary sites of hormone-dependent ovarian inhibin biosynthesis, but no equivalent data exist for primates. We have used the common marmoset (Callithrix jacchus) to investigate inhibin biosynthesis in primate granulosa cells in vitro and to determine its relationship to preovulatory follicular development. To relate the production of immunoactive inhibin to follicular maturity, we studied primary granulosa cell cultures from follicles at progressive stages of preovulatory development. Granulosa cells from 'large' (greater than or equal to 2.0 mm diameter) follicles expressed high rates of inhibin production and steroidogenesis (progesterone), and were positively regulated by human (h)LH in vitro. Less mature granulosa cells from 'medium' (1.1-1.9 mm) and 'small' (less than or equal to 1.0 mm) follicles expressed proportionately lower rates of inhibin production and steroidogenesis, but each parameter was stimulated in a dose- and time-dependent manner by hFSH in vitro. The stimulatory action of hFSH on immunoreactive inhibin was augmented by the presence of testosterone or oestradiol; testosterone (but not oestradiol) also augmented the steroidogenic response t...Continue Reading

Citations

Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·S G Hillier, F Miró
Jul 16, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Shui-Kei PoonWei Ge
Apr 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·M Tetsuka, S G Hillier
Jan 1, 1994·Duodecim; lääketieteellinen aikakauskirja·J Toppari, A Kaipia
May 12, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Vahid ZadmajidP Mark Lokman
Jul 11, 1991·Clinical Endocrinology·S G HillierA S McNeilly
May 28, 1993·Annals of the New York Academy of Sciences·S G Hillier, F Miró
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden
Jul 7, 2017·American Journal of Physiology. Endocrinology and Metabolism·Marissa KraynakDavid H Abbott
Oct 1, 1992·Journal of Endocrinological Investigation·G GiordanoF Minuto
Dec 14, 2002·Gynécologie, obstétrique & fertilité·R Fanchin

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