Control of innate-like B cell location for compartmentalised IgM production.

Current Opinion in Immunology
Lucy H Jackson-Jones, Cécile Bénézech

Abstract

Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.

Citations

Apr 13, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christine F KuperMarcel V W Wijnands
Sep 21, 2018·Nature Immunology·Joseph Chavarria-SmithMenno van Lookeren Campagne
Nov 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinkai JiaPéter Balogh
Dec 20, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Aditi UpadhyeColeen A McNamara
Feb 11, 2020·Frontiers in Endocrinology·Chloe HoggErin Greaves
Feb 23, 2019·Frontiers in Immunology·Cécile Bénézech, Lucy Helen Jackson-Jones
Aug 28, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisMichael Maes
Apr 4, 2021·International Journal of Molecular Sciences·C Frieke KuperJolanda H M van Bilsen
Oct 20, 2020·Frontiers in Immunology·Xunyao Wu

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