Control of interferon-tau gene expression by Ets-2.

Proceedings of the National Academy of Sciences of the United States of America
Toshihiko EzashiR M Roberts

Abstract

Expression of the multiple interferon-tau (IFN-tau) genes is restricted to embryonic trophectoderm of ruminant ungulate species for a few days in early pregnancy. The promoter regions of these genes are highly conserved. A proximal (bp -91 to -69) sequence has been implicated in controlling trophoblast-specific expression. Here it was used as a target for yeast one-hybrid screening of a day 13 conceptus cDNA library. Two transcription factors of the Ets family, Ets-2 and GABPalpha, were identified, consistent with the observation that active ovine IFN-tau genes contain a single 10-bp Ets motif (core: GGAA) in the proximal segment, whereas three known inactive ovine genes contain a mutated core motif (TGAA). Cotransfection of a promoter- (-126 to +50) luciferase reporter construct from an active gene (bovineIFN-tau1; boIFNT1) and an Ets-2 expression plasmid in human JAr cells provided up to a 30-fold increase in reporter expression, whereas promoters from inactive genes were not transactivated. GABPalpha alone was ineffective and had only a approximately 2-fold positive effect when coexpressed with its partner GABPbeta. Other Ets-related transcription factors, which were not detected in the genetic screen, also provided a range ...Continue Reading

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Citations

Feb 27, 2001·Molecular and Cellular Endocrinology·H YamaguchiR K Christenson
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A P AlexenkoR M Roberts
Jul 16, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Thomas W Chon, Sandra Bixler
Nov 26, 2010·Biology of Reproduction·R Michael Roberts, Susan J Fisher
Nov 17, 2010·Molecular and Cellular Biology·Andrew M ParrottMichael B Mathews
Nov 2, 2001·Molecular and Cellular Biology·T EzashiR M Roberts
Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·R Michael RobertsPadmalaya Das
May 1, 2004·The Journal of Reproduction and Development·Kazuhiko ImakawaRonald K Christenson
Jan 10, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Peter L Pfeffer, David J Pearton
Apr 23, 2013·Molecular Reproduction and Development·Toshihiro SakuraiKazuhiko Imakawa
May 1, 2013·Asian-Australasian Journal of Animal Sciences·Min-Su KimKazuhiko Imakawa
Sep 4, 2016·Human Reproduction Update·Teena Kjb GamageJoanna L James
May 12, 2016·Reproduction, Fertility, and Development·Shuan ZhaoShen-Ming Zeng
Jul 31, 2007·Cytokine & Growth Factor Reviews·R Michael Roberts
Mar 28, 2009·Theriogenology·Angela M WalkerR Michael Roberts
Feb 28, 2017·The Journal of Reproduction and Development·Takahiro ShirozuMasashi Takahashi
Feb 15, 2001·Oncogene·V I Sementchenko, D K Watson
Oct 7, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Toshihiko Ezashi, Kazuhiko Imakawa
Oct 7, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Alan D Ealy, Lydia K Wooldridge
Aug 28, 2007·Molecular Reproduction and Development·Neil C TalbotUNKNOWN U.S. Department of Agriculture, Agricultural Research Service
Jan 16, 2009·American Journal of Reproductive Immunology : AJRI·Alan D Ealy, Qi En Yang
Jun 23, 2005·Molecular Reproduction and Development·Fuko Matsuda-MinehataKazuhiko Imakawa
Feb 21, 2006·Molecular Reproduction and Development·Kazuhiko ImakawaRonald K Christenson
Dec 1, 2011·The Journal of Biological Chemistry·Ian B FisherNatarajan Muthusamy
Feb 1, 2015·Reproduction, Fertility, and Development·Isabelle Hue

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