PMID: 830892Jan 1, 1977

Control of juvenile diabetes mellitus and its relationship to endogenous insulin secretion as measured by C-peptide immunoreactivity

The Journal of Pediatrics
L A GrajwerA H Rubenstein


Proinsulin is converted to insulin and C-peptide in the pancreatic beta-cells; the latter two peptides are secreted in equimolar concentrations. Thus measurements of C-peptide immunoreactivity may provide a means of assessing residual pancreatic function in insulin-treated diabetic patients. Thirty-five patients with a mean (+/- SE) age of 13.4 +/- .6 years who had diabetes mellitus for 4.8 +/- .3 years were included in this study. Glucose and CPR were measured in the fasting state and one hour after 1 gm/kg (maximum 50 gm) of oral and glucose. Patients were assigned to one of two groups on the basis of adequate or poor control of diabetes. Twenty-five of the 35 (71%) patients had evidence of endogenous beta-cell function, i.e., CPR greater than 0.5 ng/ml. CPR levels over 0.5 ng/ml were present in a significantly (p less than 0.05) greater number of patients with diabetes of less than 5 years duration (19/21) than in those with diabetes greater than 5 years duration (6/14). Only one patient showed a rise in CPR after the glucose load. All patients with CPR greater than 2.0 ng/ml were in the adequately controlled groups, but there were patients with CPR less than 2.0 ng/ml in both adequately and poorly controlled groups. Because...Continue Reading


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Mar 1, 1980·The Journal of Pediatrics·M MenchiniG Chiumello
Sep 1, 1982·The Journal of Pediatrics·M C RudolfW V Tamborlane
May 31, 2002·The New England Journal of Medicine·Kevan C HeroldJeffrey A Bluestone
Jun 1, 1980·Australian Paediatric Journal·B A DarlowD W Beaven
Jan 1, 1977·Acta Paediatrica Scandinavica. Supplement·L G Heding, J Ludvigsson
Jan 1, 1977·Acta Paediatrica Scandinavica. Supplement·J Ludvigsson, L G Heding
Jul 27, 2006·Acta Pharmacologica Sinica·En-Guang BiBing Sun
Jun 1, 1982·Archives of Disease in Childhood·N P Mann, D I Johnston
Aug 17, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Aaron W Michels, Matthias von Herrath
Sep 1, 1977·The Journal of Pediatrics·H J HirschK H Gabbay
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb
Jun 1, 1987·Acta Paediatrica Japonica; Overseas Edition·N K MaclarenW J Riley
Feb 1, 1987·Acta Paediatrica Japonica; Overseas Edition·T KitagawaT Uragami
Jan 1, 1984·Acta paediatrica Scandinavica·M L KäärK Säkkinen
Jan 1, 1986·Diabetes/metabolism Reviews·O K Faber, C Binder
Oct 31, 2017·Diabetes, Obesity & Metabolism·Oskar Skog, Olle Korsgren
Mar 1, 1982·Archives of Disease in Childhood·A L KinmonthJ D Baum
Mar 17, 1988·The New England Journal of Medicine·Kevan C Herold, A H Rubenstein
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·S Madsbad
Jan 1, 1980·Journal of Endocrinological Investigation·D GiuglianoP J Lefebvre
Feb 13, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·M D TaylorEdinburgh Prospective Diabetes Study
Feb 5, 1987·The New England Journal of Medicine·W E WinterR P Spillar
Jul 1, 1981·Annals of Clinical Biochemistry·A M Bonser, P Garcia-Webb


Nov 1, 1975·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H OyamaN Suetsugu
Nov 16, 1968·Lancet·H Orskov, K Johansen
Nov 1, 1973·American Journal of Diseases of Children·B A PorterA M Lawrence
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·F MelaniD F Steiner
Nov 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G FinkL Recant
Sep 1, 1972·The Journal of Clinical Endocrinology and Metabolism·M B BlockA H Rubenstein
Jan 1, 1968·Diabetes·M L ParkerD M Kipnis
Mar 15, 1969·British Medical Journal·K Johansen, H Orskov
May 2, 1957·The New England Journal of Medicine·R CAMERINI-DAVALOSL SARGEANT

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