PMID: 8964906May 1, 1996Paper

Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge

Journal of Neuroimmunology
W L dos SantosD K Male

Abstract

Lymphocyte adhesion to CNS endothelium is low by comparison with non-CNS endothelium. It has been proposed that this could be due to the high surface charge of brain endothelium, or a low constitutive expression of adhesion molecules. In this study we compared the influence of these factors on lymphocyte adhesion to BEC and aortic endothelium (AEC) in culture. Brain endothelium expresses very low levels of VCAM-1, and lower levels of ICAM-1 than aortic endothelium. The negative charge differed between the endothelia, but this had a minimal effect on lymphocyte adhesion. The anionic sites were, however, more stable on brain endothelium, remaining unchanged after endothelial cell activation with cytokines, while redistribution was observed on cytokine-activated aortic endothelium.

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F WellerR R Lobb
Mar 1, 1987·Journal of Neuropathology and Experimental Neurology·M N HartP A Cancilla
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Jul 11, 1986·Neuroscience Letters·C C Hughes, P L Lantos
Sep 1, 1984·Journal of Cellular Physiology·S M MumbyP Bornstein
Jan 1, 1984·Acta Neuropathologica·S Nag
Jun 1, 1984·Biophysical Journal·G I BellP Bongrand
Apr 1, 1994·Cell Adhesion and Communication·U GotschD Vestweber
Dec 1, 1993·The American Review of Respiratory Disease·N HoggR C Landis
Jan 3, 1994·Journal of Immunological Methods·G PryceD Male
Jan 1, 1995·Acta Neuropathologica·W L dos SantosD K Male

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Citations

Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sean MarracheShanta Dhar
Jul 6, 2002·Journal of Neuroimmunology·Jean-Bernard Dietrich
Aug 31, 2000·Critical Care Medicine·M C PapadopoulosE D Bennett
Mar 4, 1998·Current Opinion in Neurology·K J Becker

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