PMID: 8978612Dec 13, 1996Paper

Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene

Cell
L C RynerS A Wasserman

Abstract

Sexual orientation and courtship behavior in Drosophila are regulated by fruitless (fru), the first gene in a branch of the sex-determination hierarchy functioning specifically in the central nervous system (CNS). The phenotypes of new fru mutants encompass nearly all aspects of male sexual behavior. Alternative splicing of fru transcripts produces sex-specific proteins belonging to the BTB-ZF family of transcriptional regulators. The sex-specific fru products are produced in only about 500 of the 10(5) neurons that comprise the CNS. The properties of neurons expressing these fru products suggest that fru specifies the fates or activities of neurons that carry out higher order control functions to elicit and coordinate the activities comprising male courtship behavior.

References

Jun 1, 1992·Trends in Neurosciences·M Burrows
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J M Belote, B S Baker
Jul 11, 1984·Nucleic Acids Research·P O O'Connell, M Rosbash
Nov 24, 1995·The Journal of Biological Chemistry·N MatsuoA Wanaka
Apr 1, 1995·Scientific American·R J Greenspan
May 19, 1995·Cell·L C Ryner, A Swain
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·S D Zhang, W F Odenwald
Jan 1, 1994·Developmental Genetics·M McKeown
Jan 1, 1994·Annual Review of Psychology·S M Breedlove
Jun 17, 1994·Science·J C Hall
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·H ItoD Yamamoto
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·B DauwalderW Mattox

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Citations

Dec 18, 2002·Journal of Neurobiology·Scott W Emmons, Jonathan Lipton
May 29, 2007·Development Genes and Evolution·Rebecca F Spokony, Linda L Restifo
Feb 23, 2011·Development Genes and Evolution·Elke ClynenMaria-Dolors Piulachs
May 3, 2005·Behavior Genetics·Jennifer M Gleason
Mar 29, 2008·Behavior Genetics·Elizabeth A Ruedi, Kimberly A Hughes
Jun 11, 2002·Biochemical and Biophysical Research Communications·Anna RadovicMark David Drapeau
Oct 1, 1998·Behavioural Brain Research·G O Pflugfelder
Oct 15, 2003·Behavioural Processes·Jean Marc Devaud
Feb 18, 1998·Current Opinion in Neurobiology·R J Greenspan
Dec 23, 1999·Current Opinion in Neurobiology·S F Goodwin
Feb 8, 2003·Current Biology : CB·Mariana F Wolfner
Oct 31, 2002·RNA·Bianca J Lam, Klemens J Hertel
Jul 30, 2004·Nature·Devanand S Manoli, Bruce S Baker
Dec 28, 2007·Nature Neuroscience·Joel D Levine
May 25, 2004·Nature Neuroscience·Stuart K Amateau, Margaret M McCarthy
Nov 23, 2006·Nature Neuroscience·Eleftheria VrontouBarry J Dickson
Sep 17, 2008·Nature Structural & Molecular Biology·Ying FengJames L Manley
May 21, 1999·European Journal of Biochemistry·C N MacDougallM Bownes
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Trudy F C MackayStephanie M Rollmann
May 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shinsuke Fujii, Hubert Amrein
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yufeng PanBruce S Baker
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anita V Devineni, Ulrike Heberlein
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·P CortesD Baltimore
Mar 21, 2003·The Journal of Biological Chemistry·Bianca J LamKlemens J Hertel
Oct 17, 1998·The EMBO Journal·B Dauwalder, W Mattox
Apr 8, 2009·Molecular Biology and Evolution·Rinaldo C BertossaLeo W Beukeboom
Dec 22, 1999·Nucleic Acids Research·S L ChewI C Eperon
Dec 1, 2006·Nucleic Acids Research·Kathryn S Sciabica, Klemens J Hertel
Sep 13, 2011·Nucleic Acids Research·Julian P VenablesFrançois Juge
Feb 23, 2011·Development, Growth & Differentiation·Ken-Ichi Kimura
Jul 16, 2003·Molecular and Cellular Biology·Dawn S ChandlerWilliam Mattox
Sep 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Luiz O F Penalva, Lucas Sánchez
Mar 11, 2003·Annual Review of Biochemistry·Douglas L Black

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