Control of memory formation through regulated expression of a CaMKII transgene

Science
M MayfordE R Kandel

Abstract

One of the major limitations in the use of genetically modified mice for studying cognitive functions is the lack of regional and temporal control of gene function. To overcome these limitations, a forebrain-specific promoter was combined with the tetracycline transactivator system to achieve both regional and temporal control of transgene expression. Expression of an activated calcium-independent form of calcium-calmodulin-dependent kinase II (CaMKII) resulted in a loss of hippocampal long-term potentiation in response to 10-hertz stimulation and a deficit in spatial memory, a form of explicit memory. Suppression of transgene expression reversed both the physiological and the memory deficit. When the transgene was expressed at high levels in the lateral amygdala and the striatum but not other forebrain structures, there was a deficit in fear conditioning, an implicit memory task, that also was reversible. Thus, the CaMKII signaling pathway is critical for both explicit and implicit memory storage, in a manner that is independent of its potential role in development.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Gossen, H Bujard
Jan 1, 1992·Annual Review of Biochemistry·P I Hanson, H Schulman
May 1, 1992·Science·J J Kim, M S Fanselow
Aug 1, 1990·The Journal of Comparative Neurology·H Kita, S T Kitai
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T Sunyer, N Sahyoun
Jan 1, 1986·Progress in Neurobiology·B H Bland
Nov 1, 1972·Journal of Comparative and Physiological Psychology·D C Blanchard, R J Blanchard
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·P M LledoR A Nicoll
Oct 1, 1994·Trends in Neurosciences·J Lisman
Apr 1, 1995·Current Opinion in Neurobiology·M MayfordE R Kandel
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·M MayfordE R Kandel
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER

❮ Previous
Next ❯

Citations

Mar 14, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christopher Rongo
Jan 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G E RobinsonM L Winston
Sep 9, 2005·Hippocampus·Robert P Vertes
Oct 31, 2002·Human Psychopharmacology·I. Hindmarch
Apr 28, 2012·Acta Neuropathologica·Ashley CannonJada Lewis
May 15, 2013·Acta Neuropathologica·Amy K ClippingerJada Lewis
Sep 26, 2009·Brain Structure & Function·Holly J GarringerRuben Vidal
Jun 19, 2012·Brain Structure & Function·Katelin F HansenKarl Obrietan
Sep 7, 2004·Cell and Tissue Research·Robert E Burke
Oct 31, 2006·Behavior Genetics·Jason L Eriksen, Christopher G Janus
Nov 13, 2008·Cytotechnology·Tobias MayDagmar Wirth
Sep 29, 2011·Molecular Neurobiology·Angel Barco, Hélène Marie
Oct 16, 2012·Molecular Neurobiology·Aron KosArmaz Aschrafi
Nov 30, 2012·Molecular Neurobiology·Katja Hochgräfe, Eva-Maria Mandelkow
Jun 19, 2013·Brain Research·Nicola J RutherfordBenoit I Giasson
May 19, 2005·Neuroscience and Biobehavioral Reviews·Martin E KeckMarianne B Müller
Jun 19, 2013·Neurobiology of Learning and Memory·Brian J Wiltgen, Kazumasa Z Tanaka
Mar 12, 2004·Progress in Neurobiology·P V Nguyen, N H Woo
Feb 6, 2004·Seminars in Cancer Biology·Sylvie GiuriatoDean W Felsher
Dec 4, 2003·Biological Psychiatry·Alexei MorozovFrancois Tronche
Oct 27, 1998·Biological Psychiatry·E J Nestler
Dec 23, 1998·Biological Psychiatry·J LeDoux
Jan 5, 2002·Journal of Psychiatric Research·Marianne B Müller, Martin E Keck
May 30, 2001·Neuroscience and Biobehavioral Reviews·A Holmes
May 14, 1998·Neuroscience and Biobehavioral Reviews·R J Nelson, K A Young

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.