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Control of nerve agent-induced seizures is critical for neuroprotection and survival

Toxicology and Applied Pharmacology

Apr 15, 2003

Tsung-Ming ShihJohn H McDonough

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Abstract

This study evaluated the potency and rapidity of some anticholinergics (atropine, biperiden, and trihexyphenidyl) and benzodiazepines (diazepam and midazolam) as an anticonvulsant treatment against seizures induced by six nerve agents (tabun, sarin, soman, cyclosarin, VR, and VX) and su...read more

Mentioned in this Paper

Osteopetrosis Lethal
Toxic Encephalitis
Atropine Sulfate Anhydrous
Pyridostigmine Bromide
Continuance of Life
Diazepam
Cholinesterase Inhibitors, Reversible
Benzodiazepines Assay
Dose-Response Relationship, Drug
Muscarinic Antagonists
2
39
Paper Details
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  • References35
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Control of nerve agent-induced seizures is critical for neuroprotection and survival

Toxicology and Applied Pharmacology

Apr 15, 2003

Tsung-Ming ShihJohn H McDonough

PMID: 12691725

DOI: 10.1016/s0041-008x(03)00019-x

Abstract

This study evaluated the potency and rapidity of some anticholinergics (atropine, biperiden, and trihexyphenidyl) and benzodiazepines (diazepam and midazolam) as an anticonvulsant treatment against seizures induced by six nerve agents (tabun, sarin, soman, cyclosarin, VR, and VX) and su...read more

Mentioned in this Paper

Osteopetrosis Lethal
Toxic Encephalitis
Atropine Sulfate Anhydrous
Pyridostigmine Bromide
Continuance of Life
2
39

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Paper Details
References
  • References35
  • Citations1261
1234
  • References35
  • Citations1261
12345...

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