PMID: 9523529Apr 2, 1998Paper

Control of NO concentration in solutions of nitrosothiol compounds by light

Photochemistry and Photobiology
V R ZhelyaskovD W Godwin

Abstract

We studied the thermal and photolytic decomposition of two S-nitrosothiols, S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP), in water or propanol solutions. A "concentration clamp" (relatively constant concentration of NO as a function of time) could be implemented in a closed volume by varying the pH, concentration of nitrovasodilator and intensity of the light source. Depending on the conditions, the light either stimulated NO release or sharply decreased NO concentration in the test solutions. Changes in the absorption spectra of GSNO solutions were monitored as a function of light exposure. Generation of superoxide as a product of a photolytic decomposition reaction of S-nitrosothiols and further oxidation of NO is the most likely mechanism for light suppression of NO concentration.

Citations

Nov 4, 2008·Free Radical Biology & Medicine·Michael T ForresterJonathan S Stamler
May 31, 2012·Chemical Biology & Drug Design·Niroshini M GilesGregory I Giles
May 26, 1999·Nitric Oxide : Biology and Chemistry·V R Zhelyaskov, D W Godwin
Oct 27, 1999·Nitric Oxide : Biology and Chemistry·V R Zhelyaskov, D W Godwin

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