Control of oscillation periods and phase durations in half-center central pattern generators: a comparative mechanistic analysis.

Journal of Computational Neuroscience
Silvia DaunIlya A Rybak

Abstract

Central pattern generators (CPGs) consisting of interacting groups of neurons drive a variety of repetitive, rhythmic behaviors in invertebrates and vertebrates, such as arise in locomotion, respiration, mastication, scratching, and so on. These CPGs are able to generate rhythmic activity in the absence of afferent feedback or rhythmic inputs. However, functionally relevant CPGs must adaptively respond to changing demands, manifested as changes in oscillation period or in relative phase durations in response to variations in non-patterned inputs or drives. Although many half-center CPG models, composed of symmetric units linked by reciprocal inhibition yet varying in their intrinsic cellular properties, have been proposed, the precise oscillatory mechanisms operating in most biological CPGs remain unknown. Using numerical simulations and phase-plane analysis, we comparatively investigated how the intrinsic cellular features incorporated in different CPG models, such as subthreshold activation based on a slowly inactivating persistent sodium current, adaptation based on slowly activating calcium-dependent potassium current, or post-inhibitory rebound excitation, can contribute to the control of oscillation period and phase durat...Continue Reading

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Citations

May 13, 2011·Biological cybernetics·Kiyotoshi Matsuoka
Jul 20, 2011·Biological cybernetics·Silvia Daun-Gruhn, Ansgar Büschges
Feb 1, 2012·Biological cybernetics·Silvia Daun-GruhnAnke Borgmann
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Oct 12, 2010·Journal of Computational Neuroscience·Jonathan E RubinIlya A Rybak
Dec 18, 2010·Journal of Computational Neuroscience·Silvia Daun-Gruhn, Tibor Istvan Tóth
Mar 5, 2013·Journal of Computational Neuroscience·Calvin Zhang, Timothy J Lewis
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