PMID: 2113875May 7, 1990Paper

Control of production of insulin-like growth factor I by pig Leydig and Sertoli cells cultured alone or together. Cell-cell interactions

Molecular and Cellular Endocrinology
D NavilleJ M Saez

Abstract

The production of insulin-like growth factor I (IGF-I) by pig Leydig cells and pig Sertoli cells cultured alone or together was investigated. Human chorionic gonadotropin (hCG) and basic fibroblast growth factor (FGF) stimulate in a dose-dependent manner IGF-I production by Leydig cells. At maximal concentrations the effects of both factors were almost additive. Insulin at micromolar concentrations enhanced IGF-I production and potentiated the effects of hCG and FGF. The secretion of IGF-I by Sertoli cells was stimulated by FSH and FGF. Under basal conditions, the production of IGF-I by the coculture was similar to the addition of the production by each cell cultured alone. In contrast, in the presence of hCG, FSH or FGF, the production of IGF-I by the coculture largely exceeded that expected from the monocultures. Moreover, stimulation of the coculture with both hCG and FSH resulted in a further increase in IGF-I production. These results indicate that Leydig as well as Sertoli cells secrete IGF-I and that the secretion of both cell types is stimulated by the corresponding gonadotropin. In addition, they indicate that Leydig-Sertoli interactions play a role in the control of IGF-I production, supporting the contention that thi...Continue Reading

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Citations

Jul 28, 1999·Molecular Reproduction and Development·M K DyckF Pothier
Jul 1, 1992·Cell Biology and Toxicology·H LejeuneJ M Saez
Mar 10, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justine BacchettaPierre Cochat
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·O AvalletJ M Saez
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·F Zhou-LiJ André
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·C Le RoyD Langlois
Mar 19, 2004·Biology of Reproduction·Varadaraj ChandrashekarAndrzej Bartke
Apr 1, 1994·Acta Paediatrica. Supplement·P G ChatelainJ M Saez
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar
Jul 5, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Z FuH Kato
Aug 13, 2003·Cell Transplantation·Dwaine F EmerichCraig R Halberstadt
Mar 27, 2019·Cell Proliferation·Sara ChiappalupiGuglielmo Sorci
Mar 6, 1999·Endocrinology·V ChandrashekarJ J Kopchick
Mar 28, 2020·Environmental Science and Pollution Research International·Ahmed S MandourGen Watanabe
Jan 1, 1992·Journal of Endocrinological Investigation·G GiordanoF Minuto
Apr 1, 1993·Journal of Endocrinological Investigation·M L Brandi
May 2, 2019·Frontiers in Endocrinology·Silvina Beatriz MeroniSelva Beatriz Cigorraga
May 30, 2021·Journal of Endocrinological Investigation·M K YilmazP Kadioglu
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·B P Mullaney, M K Skinner

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