Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3

Scientific Reports
Fei GaoSanjoy K Das

Abstract

Appropriate regulation of regional uterine stromal cell decidualization in implantation, at the mesometrial triangle and secondary decidual zone (SDZ) locations, is critical for successful pregnancy, although the regulatory mechanisms remain poorly understood. In this regard, the available animal models that would specifically allow mechanistic analysis of site-specific decidualization are strikingly limited. Our study found that heightened expression of FoxM1, a Forkhead box transcription factor, is regulated during decidualization, and its conditional deletion in mice reveals failure of implantation with regional decidualization defects such as a much smaller mesometrial decidua with enlarged SDZ. Analysis of cell cycle progression during decidualization both in vivo and in vitro demonstrates that the loss of FoxM1 elicits diploid cell deficiency with enhanced arrests prior to mitosis and concomitant upregulation of polyploidy. We further showed that Hoxa10 and cyclin D3, two decidual markers, control transcriptional regulation and intra-nuclear protein translocation of FoxM1 in polyploid cells, respectively. Overall, we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstrea...Continue Reading

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Citations

Jan 26, 2016·American Journal of Reproductive Immunology : AJRI·Arpita S BhurkeMilan K Bagchi
May 18, 2016·Scientific Reports·Fenghua BianSanjoy K Das
Aug 25, 2018·PLoS Biology·Eric M ErkenbrackGünter P Wagner
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Jun 14, 2018·Experimental and Therapeutic Medicine·Xuena CuiYuanhua Ye
Mar 21, 2019·Animal Models and Experimental Medicine·Bo HeHai-Bin Wang
Jun 13, 2021·Reproductive Biology and Endocrinology : RB&E·Shijian LvCong Zhang
Oct 31, 2021·Reproductive Biology and Endocrinology : RB&E·Peng-Chao WangZeng-Ming Yang

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Methods Mentioned

BETA
immunoprecipitation
ChIP
ubiquitination
nuclear translocation
PCR
flow cytometry

Software Mentioned

Image J

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