Control of Regulatory T Cell Migration, Function, and Homeostasis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Daniel J Campbell

Abstract

Foxp3(+) regulatory T cells (Tregs) are essential for preventing autoimmunity and uncontrolled inflammation, and they modulate immune responses during infection and the development of cancer. Accomplishing these tasks requires the widespread distribution of Tregs in both lymphoid and nonlymphoid tissues, and the selective recruitment of Tregs to different tissue sites has emerged as a key checkpoint that controls tissue inflammation in autoimmunity, infection, and cancer development, as well as in the context of allograft acceptance or rejection. Additionally, Tregs are functionally diverse, and it has become clear that some of this diversity segregates with Treg localization to particular tissue sites. In this article, I review the progress in understanding the mechanisms of Treg trafficking and discuss factors controlling their homeostatic maintenance and function in distinct tissue sites.

References

Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A LutherJ G Cyster
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Jul 4, 2003·Nature·J Rodrigo MoraUlrich H Von Andrian
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Aug 17, 2004·Immunity·Chyi-Song HsiehAlexander Y Rudensky
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shin MakitaMamoru Watanabe
Oct 16, 2004·Immunity·Makoto IwataSi-Young Song
Jan 12, 2005·The Journal of Experimental Medicine·J Rodrigo MoraUlrich H von Andrian
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy L DenningMitchell Kronenberg
Nov 29, 2005·Nature Immunology·Qizhi TangJeffrey A Bluestone
Mar 15, 2006·The Journal of Experimental Medicine·Carlos E TadokoroMichael L Dustin
Jul 5, 2006·The Journal of Experimental Medicine·Weihong LiuJeffrey A Bluestone
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Meixiao Long, Adam J Adler
Oct 4, 2006·The Journal of Experimental Medicine·Ekaterina YurchenkoCiriaco A Piccirillo
Dec 1, 2006·Nature Immunology·Jeong M KimAlexander Y Rudensky
Jun 6, 2007·The Journal of Experimental Medicine·Blythe D SatherDaniel J Campbell
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yvonne BurmeisterAndreas Hutloff
Jun 25, 2008·The Journal of Experimental Medicine·Jan C DuddaDaniel J Campbell
Aug 20, 2008·The Journal of Experimental Medicine·John AnderssonEthan M Shevach
Aug 20, 2008·The Journal of Experimental Medicine·Elin JaenssonWilliam W Agace
Oct 11, 2008·Science·Kajsa WingShimon Sakaguchi
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohide YamazakiChen Dong
Aug 4, 2010·The Journal of Experimental Medicine·Yenkel Grinberg-BleyerEliane Piaggio
Sep 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johnna D WesleyDaniel J Campbell
Oct 19, 2010·Nature Immunology·Lauren W CollisonDario A A Vignali
Nov 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luke BarronAbul K Abbas
Jan 27, 2011·Nature Reviews. Immunology·Daniel J Campbell, Meghan A Koch
Jul 15, 2011·Nature·Andrea FacciabeneGeorge Coukos

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Citations

Feb 3, 2016·Frontiers in Immunology·Ana Luisa PerdigotoKevan C Herold
Apr 19, 2016·The Journal of Clinical Investigation·Zhenke WenCornelia M Weyand
Oct 14, 2016·JCI Insight·Epameinondas GousopoulosMichael Detmar
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·Michael R Yeaman, John P Hennessey
Sep 15, 2016·Scientific Reports·Maria L BreserVirginia E Rivero
Feb 24, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christian MorathChristian Kleist
Jan 25, 2017·Advanced Healthcare Materials·Catia S VerbekeDavid J Mooney
Nov 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott HaskettMichael Mingueneau
Jan 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hung-An TingNicholas W Lukacs
May 17, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R E HoeppliM K Levings
Aug 1, 2018·Current Opinion in Organ Transplantation·Antoine SicardMegan K Levings
May 11, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyunseong KimHyunsu Bae
Dec 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jenna M SullivanDaniel J Campbell
Jul 1, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Tom M A Wilkinson
May 24, 2016·Journal of Clinical Immunology·Eric Allenspach, Troy R Torgerson
Dec 17, 2015·Parasite Immunology·A FleuryE Sciutto
Oct 7, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Giulia CocoReza Dana
Aug 18, 2017·Current Opinion in Allergy and Clinical Immunology·Sara Ciullini Mannurita, Eleonora Gambineri
Sep 7, 2017·Immunology and Cell Biology·Emma M CarringtonAndrew M Lew
Apr 8, 2016·Current Opinion in Pediatrics·Lesley Doughty
Aug 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison C Billroth-MacLurgDeborah J Fowell
Jun 8, 2017·Frontiers in Pediatrics·Elena Martín-OrozcoJavier Martínez-García
Nov 9, 2018·Frontiers in Immunology·Babita AgrawalJeffrey D Konowalchuk
May 12, 2020·Frontiers in Oncology·Vita Fedele, Davide Melisi
Jun 5, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica HarakalKenneth S Tung
Aug 23, 2018·Frontiers in Immunology·Ivan Shevchenko, Alexandr V Bazhin
Mar 14, 2019·Journal of the National Cancer Institute·Ayman J OweidaSana D Karam
Nov 5, 2019·Frontiers in Immunology·Guoping DengMark I Greene
May 1, 2020·Cellular and Molecular Life Sciences : CMLS·Ke Wang, Wenxian Fu
Apr 30, 2016·Clinical Science·G Ryan Crislip, Jennifer C Sullivan
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claire N Spottiswoode, Robert Busch

❮ Previous
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