Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors.

Circulation Research
W A CorsiniM D Bailie

Abstract

Experiments were undertaken to investigate further the effect of furosemide on renin secretion in the anesthetized dog. To separate the effects of the macula densa and the baroreceptor mechanisms, experiments were conducted in kidneys made nonfiltering by combining 2.5 hours of renal ischemia with ureteral ligation. Furosemide, in a dose of 5 mg/kg, increased renin secretion and decreased renal resistance in dogs with a nonfiltering kidney. Prior dilation of the nonfiltering kidney with either acetylcholine or papaverine prevented changes in both resistance and renin secretion. However, following dilation of the intact filtering kidney with acetylcholine, furosemide caused an increase in renin secretion. Infusion of d,l-propranolol decreased renin secretion in both the filtering and the nonfiltering kidneys. Following propranolol treatment, furosemide increased renin secretion in the filtering kidney but had no effect on renal resistance. These experiments indicate that furosemide stimulates renin secretion by both the macula densa and the baroreceptor mechanisms. The data suggest that stimulation of the sympathetic nervous system may alter renin secretion by modulating the renal baroreceptor, but sympathetic innervation does n...Continue Reading

References

Feb 1, 1973·The American Journal of Physiology·M D BailieR Loutzenhiser
Aug 1, 1974·The American Journal of Physiology·R W GotshallJ A Johnson
Oct 1, 1968·The American Journal of Physiology·P MeyerP Milliez
Oct 1, 1955·The Journal of Clinical Investigation·M WALSERJ ORLOFF
Aug 30, 1963·Science·S L SKINNERI H PAGE
Jul 1, 1964·Circulation Research·S L SKINNERI H PAGE
Sep 1, 1964·The American Journal of Physiology·A J VANDER, R MILLER

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Citations

Feb 22, 1978·Pflügers Archiv : European journal of physiology·B GrandjeanJ Sassard
Jul 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J R IngelfingerV J Dzau
Aug 15, 1986·European Journal of Pharmacology·T Shimizu, M Nakamura
Jan 1, 1982·Pharmacology & Therapeutics·B Noordewier, J B Hook
Oct 9, 2003·Kidney International·Nina Vasavada, Rajiv Agarwal
Mar 1, 1988·Acta Physiologica Scandinavica·J F BuggeF Kiil
Aug 18, 2005·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann
Jan 1, 1997·Journal of Endocrinological Investigation·N FukudaK Kanmatsuse
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·M L TuckJ Barrett
Jun 1, 1981·Kidney International·J G GerberA S Nies
Dec 1, 1977·Kidney International·K L DuchinT J Burke
Mar 1, 1989·Kidney International·D Y LeeC S Park
Nov 1, 1977·Clinics in Endocrinology and Metabolism·J B Young, L Landsberg
Mar 26, 2005·The Journal of Small Animal Practice·P J SmithJ Dukes-McEwan
Nov 1, 1986·Journal of Clinical Pharmacology·D E Hutcheon, J C Martinez
Nov 22, 2011·Seminars in Nephrology·Sagar U Nigwekar, Sushrut S Waikar
Jul 1, 1979·Circulation Research·A A Seymour, J E Zehr
Jan 1, 1995·Canadian Journal of Physiology and Pharmacology·F G Smith, J Abraham
May 1, 1976·Circulation Research·W A PettingerD C Harper
Dec 12, 2001·American Journal of Physiology. Renal Physiology·Silene L S PiresChristian Barrès
Jan 1, 1988·Scandinavian Journal of Urology and Nephrology·P A SjöströmM Hammarlund-Udenaes
Jun 1, 1984·British Journal of Pharmacology·A E BardenR Vandongen
Feb 26, 2016·American Journal of Physiology. Renal Physiology·Xiaohua HuangBranko Braam
Jan 1, 1977·Acta Pharmacologica Et Toxicologica·U B Olsen
May 1, 1979·Circulation Research·M D Thames, G F DiBona
Dec 1, 1979·Circulation Research·P C ChurchillF D McDonald
Dec 1, 1982·Circulation Research·S SpitalewitzJ G Porush
Aug 1, 1984·Kidney International·B J Tucker, R C Blantz

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