Control of Rubisco function via homeostatic equilibration of CO2 supply

Frontiers in Plant Science
Abir U Igamberdiev

Abstract

Rubisco is the most abundant protein on Earth that serves as the primary engine of carbon assimilation. It is characterized by a slow rate and low specificity for CO2 leading to photorespiration. We analyze here the challenges of operation of this enzyme as the main carbon fixation engine. The high concentration of Rubisco exceeds that of its substrate CO2 by 2-3 orders of magnitude; however, the total pool of available carbon in chloroplast, i.e., mainly bicarbonate, is comparable to the concentration of Rubisco active sites. This makes the reactant stationary assumption (RSA), which is essential as a condition of satisfying the Michaelis-Menten (MM) kinetics, valid if we assume that the delivery of CO2 from this pool is not limiting. The RSA is supported by active carbonic anhydrases (CA) that quickly equilibrate bicarbonate and CO2 pools and supply CO2 to Rubisco. While the operation of stromal CA is independent of light reactions, the thylakoidal CA associated with PSII and pumping CO2 from the thylakoid lumen is coordinated with the rate of electron transport, water splitting and proton gradient across the thylakoid membrane. At high CO2 concentrations, CA becomes less efficient (the equilibrium becomes unfavorable), so a ...Continue Reading

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Feb 13, 2015·Frontiers in Plant Science·Abir U Igamberdiev, Leszek A Kleczkowski

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Citations

Apr 19, 2016·Physiologia Plantarum·Per Gardeström, Abir U Igamberdiev
Jul 12, 2019·Journal of Experimental Botany·Maricruz GonzálezFrancisco Javier Cejudo
Jan 23, 2020·The Biochemical Journal·Leszek A Kleczkowski, Abir U Igamberdiev
Feb 23, 2021·Frontiers in Genetics·Susana González-MoralesAdalberto Benavides-Mendoza
Nov 18, 2018·Progress in Biophysics and Molecular Biology·Abir U Igamberdiev, Leszek A Kleczkowski

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Methods Mentioned

BETA
RSA
transgenic

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