Control of secondary hyperparathyroidism by vitamin D receptor agonists in chronic kidney disease

Clinical Journal of the American Society of Nephrology : CJASN
Stuart M Sprague, Daniel W Coyne

Abstract

Effective treatment options for managing secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) have advanced steadily since the early 1980s, from surgical removal of the parathyroid gland to pharmacologic intervention focused on reestablishing hormonal and mineral balances. In addition, earlier recognition of CKD via estimated GFR and educational efforts have led to advancements in diagnosis and treatment of elevated parathyroid hormone (PTH) and vitamin D deficiency. Clinical studies support the efficacy and safety of vitamin D receptor (VDR) agonists as effective treatments for SHPT. A number of considerations to ensure optimal SHPT control in CKD patients are apparent. VDR agonists effectively treat SHPT and vitamin D deficiency, but dosing needs to be optimized for each patient because the patient responds in an individualized manner to treatment to suppress and stabilize PTH levels. VDR agonist therapy should be continuous to ensure continued PTH suppression, coupled with strict monitoring of calcium and phosphorus to ensure compliance within target ranges. Awareness of the complex and beneficial effects of VDR agonists contributes to improved benefits in bone mineral disease and lower mortalit...Continue Reading

References

Aug 3, 1989·The New England Journal of Medicine·D L AndressD J Sherrard
Jan 1, 1986·Journal of Molecular and Cellular Cardiology·M R WaltersP C Riggle
Nov 1, 1988·The Journal of Clinical Endocrinology and Metabolism·T O PittsJ B Puschett
May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C GallagherH F DeLuca
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C W ParkB K Bang
Jan 14, 2000·Kidney International. Supplement·E SlatopolskyA Dusso
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M FrazãoJ W Coburn
Mar 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H M MaungJ W Coburn
Nov 14, 2002·Seminars in Nephrology·L Tammy Ho, Stuart M Sprague
Mar 13, 2003·Kidney International·Stuart M SpragueDaniel Batlle
Aug 2, 2003·The New England Journal of Medicine·Ming TengRavi Thadhani
Dec 17, 2003·Kidney International·Bryan KestenbaumCatherine O Stehman-Breen
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marianne RixKlaus Olgaard
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jack W CoburnCharles W Bishop
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Wei XiangYan Chun Li
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Josef CoreshThomas H Hostetter
Dec 24, 2004·Journal of the American Society of Nephrology : JASN·Bryan KestenbaumDennis L Andress
Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Ming TengRavi Thadhani
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Daniel CoyneStuart M Sprague
Oct 6, 2006·Kidney International·F TentoriUNKNOWN Medical Directors of Dialysis Clinic Inc
Jan 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lourdes CraverElvira Fernández
Apr 6, 2007·Kidney International·K R NevesR M A Moysés
Jun 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ziyad Al-AlyKevin J Martin
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Aug 10, 2007·Kidney International·M WolfR Thadhani
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Natalya BodyakPeter M Kang
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Jan 9, 2008·Circulation·Thomas J WangRamachandran S Vasan
Feb 2, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Prakash ChandraVin Tangpricha
Feb 27, 2008·Archives of Internal Medicine·Csaba P KovesdyKamyar Kalantar-Zadeh
Mar 14, 2008·Kidney International·D L Andress
May 9, 2008·Journal of the American Society of Nephrology : JASN·Abigail B ShobenBryan Kestenbaum
Jul 18, 2008·Kidney International·Manuel Naves-DíazJorge B Cannata-Andía
Oct 10, 2008·Kidney International·Pietro RavaniCarmine Zoccali
Apr 7, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katrin UhligStanley Goldfarb

❮ Previous
Next ❯

Citations

Jan 9, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B J EdwardsM Favus
Sep 20, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Won Seok YangSu-Kil Park
Jun 28, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Daniel W CoyneStuart M Sprague
Aug 23, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Paul D Miller
Mar 5, 2013·Pharmacological Reviews·Thomas P BurrisDouglas J Kojetin
Dec 22, 2019·European Journal of Clinical Investigation·Graziella D'ArrigoCarmine Zoccali
Oct 30, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Stuart M Sprague
Sep 6, 2019·Current Osteoporosis Reports·Ezequiel Bellorin-FontKevin J Martin
Jul 12, 2017·International Urology and Nephrology·Rosilene M Elias, Rosa M A Moysés
May 29, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Ryyan Hyder, Stuart M Sprague

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.