Control of secondary metabolism by farX, which is involved in the gamma-butyrolactone biosynthesis of Streptomyces lavendulae FRI-5

Archives of Microbiology
Shigeru KitaniTakuya Nihira

Abstract

The gamma-butyrolactone signaling system is distributed widely among streptomycetes as an important regulatory mechanism of antibiotic production and/or morphological differentiation. IM-2 [(2R,3R,1'R)-2-(1'-hydroxybutyl)-3-hydroxymethyl-gamma-butanolide] is a gamma-butyrolactone that switches off the production of D: -cycloserine but switches on the production of several nucleoside antibiotics as well as blue pigment in Streptomyces lavendulae FRI-5. farX is a member of the afsA-family genes, which are proposed to encode enzymes involved in gamma-butyrolactone biosynthesis. Disruption of farX caused overproduction of D: -cycloserine, and abolished production of nucleoside antibiotic and blue pigment with the loss of IM-2 production. The finding that all phenotypic changes observed in the farX disruptant were restored by the addition of exogenous IM-2 suggested that FarX plays a biosynthetic role in IM-2 production. Transcriptional comparison between the wild-type strain and the farX disruptant revealed that, in addition to already known genes farR1 and farR2, several other genes (farR4, farD, and farE) are under the transcriptional regulation of IM-2. Furthermore, the fact that farX transcription is under the control of IM-2 s...Continue Reading

References

Feb 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jun-ya KatoSueharu Horinouchi
Feb 8, 2007·Bioscience, Biotechnology, and Biochemistry·Sueharu Horinouchi

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Citations

Apr 25, 2013·The Journal of Antibiotics·Arryn CraneyJustin Nodwell
Aug 16, 2014·Applied Microbiology and Biotechnology·Yohanes Novi KurniawanTakuya Nihira
Sep 17, 2015·Journal of Bioscience and Bioengineering·Yohanes Novi KurniawanTakuya Nihira
Jun 12, 2016·FEMS Microbiology Reviews·Guoqing NiuHuarong Tan
May 4, 2018·Natural Product Reports·Helga U van der HeulGilles P van Wezel

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