Abstract
The gamma-butyrolactone signaling system is distributed widely among streptomycetes as an important regulatory mechanism of antibiotic production and/or morphological differentiation. IM-2 [(2R,3R,1'R)-2-(1'-hydroxybutyl)-3-hydroxymethyl-gamma-butanolide] is a gamma-butyrolactone that switches off the production of D: -cycloserine but switches on the production of several nucleoside antibiotics as well as blue pigment in Streptomyces lavendulae FRI-5. farX is a member of the afsA-family genes, which are proposed to encode enzymes involved in gamma-butyrolactone biosynthesis. Disruption of farX caused overproduction of D: -cycloserine, and abolished production of nucleoside antibiotic and blue pigment with the loss of IM-2 production. The finding that all phenotypic changes observed in the farX disruptant were restored by the addition of exogenous IM-2 suggested that FarX plays a biosynthetic role in IM-2 production. Transcriptional comparison between the wild-type strain and the farX disruptant revealed that, in addition to already known genes farR1 and farR2, several other genes (farR4, farD, and farE) are under the transcriptional regulation of IM-2. Furthermore, the fact that farX transcription is under the control of IM-2 s...Continue Reading
References
Jan 15, 1992·The Journal of Biological Chemistry·S OkamotoY Yamada
Jul 1, 1992·Gene·M BiermanB E Schoner
Dec 1, 1988·The Journal of Antibiotics·T NihiraY Yamada
Aug 1, 1997·Journal of Bacteriology·M WakiY Yamada
Dec 29, 1998·Journal of Bacteriology·M S PagetM J Buttner
Jul 20, 1999·Molecular Microbiology·M S PagetM J Buttner
Aug 10, 1999·Journal of Bacteriology·S KitaniY Yamada
Feb 5, 2000·Molecular & General Genetics : MGG·T DairiH Seto
Feb 7, 2001·The Journal of Biological Chemistry·E TakanoM Bibb
May 3, 2000·Molecular Microbiology·R KawachiY Yamada
Jun 22, 2001·Journal of Bacteriology·S KitaniT Nihira
Sep 14, 2001·Molecular Microbiology·E TakanoM J Bibb
Aug 24, 2002·Journal of Bacteriology·Noriyasu ShikuraTakuya Nihira
Oct 3, 2003·Archives of Microbiology·Sun-Uk ChoiTakuya Nihira
Mar 19, 2004·Journal of Bacteriology·Jun-ya KatoSueharu Horinouchi
Apr 9, 2005·Molecular Microbiology·Eriko TakanoKeith Chater
May 6, 2006·Current Opinion in Microbiology·Eriko Takano
Feb 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jun-ya KatoSueharu Horinouchi
Feb 8, 2007·Bioscience, Biotechnology, and Biochemistry·Sueharu Horinouchi
Jan 29, 2008·Archives of Microbiology·Kang-Mu LeeYong-Il Hwang
Sep 2, 2008·Gene·Shigeru KitaniTakuya Nihira
Citations
Apr 25, 2013·The Journal of Antibiotics·Arryn CraneyJustin Nodwell
Sep 11, 2012·Applied and Environmental Microbiology·Aiyada AroonsriTakuya Nihira
Sep 29, 2011·Applied and Environmental Microbiology·Yi-Ling DuYong-Quan Li
Feb 25, 2014·Applied Microbiology and Biotechnology·Zahra Salehi-NajafabadiJuan F Martín
Aug 16, 2014·Applied Microbiology and Biotechnology·Yohanes Novi KurniawanTakuya Nihira
Sep 3, 2011·Molecular Microbiology·Juan WangKeqian Yang
Aug 15, 2014·Molecular Microbiology·Zhengzhong ZouHuarong Tan
Sep 17, 2015·Journal of Bioscience and Bioengineering·Yohanes Novi KurniawanTakuya Nihira
Sep 16, 2014·Applied Microbiology and Biotechnology·Erik MingyarJan Kormanec
Jun 12, 2016·FEMS Microbiology Reviews·Guoqing NiuHuarong Tan
May 4, 2018·Natural Product Reports·Helga U van der HeulGilles P van Wezel
Sep 28, 2017·The Journal of Antibiotics·Nguyen B ThaoTakuya Nihira
Apr 19, 2018·Applied Microbiology and Biotechnology·Dongxu MaJianping Wen
Jan 5, 2020·Applied Microbiology and Biotechnology·Yuwei ZhangYihua Chen
Mar 1, 2018·The Journal of Organic Chemistry·Abhijeet M SarkaleChandrakumar Appayee