Control of size and excitability of mechanosensory receptive fields in dorsal column nuclei by homolateral dorsal horn neurons

Journal of Neurophysiology
R W Dykes, A D Craig

Abstract

Both accidental and experimental lesions of the spinal cord suggest that neuronal processes occurring in the spinal cord modify the relay of information through the dorsal column-lemniscal pathway. How such interactions might occur has not been adequately explained. To address this issue, the receptive fields of mechanosensory neurons of the dorsal column nuclei were studied before and after manipulation of the spinal dorsal horn. After either a cervical or lumbar laminectomy and exposure of the dorsal column nuclei in anesthetized cats, the representation of the hindlimb or of the forelimb was defined by multiunit recordings in both the dorsal column nuclei and in the ipsilateral spinal cord. Next, a single cell was isolated in the dorsal column nuclei, and its receptive field carefully defined. Each cell could be activated by light mechanical stimuli from a well-defined cutaneous receptive field. Generally the adequate stimulus was movement of a few hairs or rapid skin indentation. Subsequently a pipette containing either lidocaine or cobalt chloride was lowered into the ipsilateral dorsal horn at the site in the somatosensory representation in the spinal cord corresponding to the receptive field of the neuron isolated in the...Continue Reading

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Citations

Aug 16, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Megan N MurphyScott A Smith
Apr 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Chia-Chi LiaoJon H Kaas
Dec 24, 1998·Journal of Neurophysiology·M TommerdahlB L Whitsel
Jun 29, 2005·The Journal of Comparative Neurology·Xin Wang, John T Wall
May 27, 2014·Frontiers in Systems Neuroscience·Hui-Xin QiJamie L Reed
Mar 20, 2015·Experimental Brain Research·Lee D WalshPatrick Haggard
Aug 18, 2000·The European Journal of Neuroscience·A Canedo, J Aguilar
Jul 16, 2003·The European Journal of Neuroscience·Per JenmalmRoland S Johansson
Nov 17, 2010·Molecular Psychiatry·R ShechterA Rolls
May 18, 2013·The Journal of Comparative Neurology·Charnese BowesJon Kaas
Nov 19, 2020·Journal of Clinical and Experimental Neuropsychology·Pietro CaggianoGianna Cocchini
Apr 21, 2012·Neuroscience and Biobehavioral Reviews·Dirk De RidderWalter Freeman

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