Control of skeletal muscle metabolic properties by the nuclear receptor corepressor RIP140

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Asmaà Fritah

Abstract

The transcriptional control of metabolism in response to environmental changes plays an important role in energy homeostasis. A number of nuclear receptors control both anabolic and catabolic pathways in metabolic tissues. Their transcriptional activity is mediated by recruitment of coactivators or corepressors to target genes. The corepressor receptor-interacting protein 140 (RIP140) is recruited by many nuclear receptors, including peroxisome proliferator-activated receptors and estrogen-related receptors, and by a number of other transcription factors such as nuclear receptor factor 1. It is responsible for the suppression of gene networks that control catabolism in adipose tissue and skeletal muscle, including glucose uptake, glycolysis, tricarboxylic acid cycle, fatty-acid oxidation, mitochondrial biogenesis, oxidative phosphorylation, and mitochondrial uncoupling. In this review, we focus on the role of RIP140 in regulating energy expenditure and highlight issues to address RIP140 action in skeletal muscle.

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Related Concepts

Metabolic Process, Cellular
NRIP1 wt Allele
Biochemical Pathway
Transcriptional Regulation
Co-Repressor Proteins
NRIP1 protein, human
Peroxisome Proliferator-Activated Receptors
Energy Metabolism
Transcription, Genetic
Nuclear Receptor Co-Repressor 1

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