Control of TGF-beta receptor expression in bone

Frontiers in Bioscience : a Journal and Virtual Library
M CentrellaT L McCarthy

Abstract

Bone growth and remodeling are controlled by local and systemic growth factors. The first local bone growth factor purified to homogeneity was transforming growth factor type beta (TGF-beta). On skeletal cells, TGF-beta has multiple effects mediated through at least three distinct cell surface receptors. More recent evidence demonstrated hormone and growth factor dependent alterations in TGF-beta receptor expression on osteoblasts in vitro. Indeed, certain biological responses appear to depend on the proportional expression of the type I TGF-beta receptor. Studies defining the type I TGF-beta receptor gene promoter then revealed that it contained several binding sequences for a nuclear factor that varies in parallel with expression of the osteoblast phenotype. New observations linking these events appear to enhance our understanding of this pivotal growth factor during osteogenesis and systemic bone disease.

Citations

Oct 26, 2005·Journal of Cellular Physiology·Megan A ForemanStephen J Publicover
Apr 2, 2008·American Journal of Physiology. Endocrinology and Metabolism·Cécilie DufourPierre J Marie
Jan 23, 2016·Journal of Tissue Engineering·Hye-Sun YuIvan Wall
Mar 16, 2016·Journal of Tissue Engineering·Hye-Sun YuIvan Wall

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