Control of the Cell Cycle in Adult Neurogenesis and its Relation with Physical Exercise

Brain Plasticity
Stefano Farioli-Vecchioli, Felice Tirone

Abstract

In the adult brain the neurogenesis is mainly restricted to two neurogenic regions: newly generated neurons arise at the subventricular zone (SVZ) of the lateral ventricle and at the subgranular zone of the hippocampal subregion named the dentate gyrus. The hippocampus is involved in learning and memory paradigms and the generation of new hippocampal neurons has been hypothesized to be a pivotal form of plasticity involved in the process. Moreover the dysregulation of hippocampal adult neurogenesis has been recognized and could anticipate several varieties of brain disease such as Alzheimer disease, epilepsy and depression. Over the last few decades numerous intrinsic, epigenetic and environmental factors have been revealed to deeply influence the process of adult neurogenesis, although the underlying mechanisms remain largely unknown. Growing evidence indicates that physical exercise represents one of the main extrinsic factor able to profoundly increase hippocampal adult neurogenesis, by altering neurochemistry and function of newly generated neurons. The present review surveys how neurogenesis can be modulated by cell cycle kinetics and highlights the putative role of the cell cycle length as a key component of the beneficia...Continue Reading

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Citations

May 8, 2019·Molecular Neurobiology·Vittoria Nicolis di RobilantStefano Farioli Vecchioli
Jun 4, 2020·Annals of the New York Academy of Sciences·Chi Him PoonLee Wei Lim
Feb 23, 2019·Frontiers in Cellular Neuroscience·Laura MicheliFelice Tirone
Oct 9, 2015·Brain Plasticity·Henriette van Praag, Brian Christie
Oct 14, 2018·Cellular and Molecular Neurobiology·Marlene Sinai Melo-SalasAngélica Zepeda

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