Control of the chromatin response to DNA damage: Histone proteins pull the strings.

Seminars in Cell & Developmental Biology
Juliette FerrandSophie E Polo

Abstract

DNA damage challenges both genome integrity and its organization with histone proteins into chromatin, with prominent alterations in histone variant dynamics and histone modifications. While these alterations jeopardize epigenome stability, they are also instrumental for an efficient and timely response to DNA damage. Here, we review recent findings illustrating how histone variants and post-translational modifications actively contribute to and control the DNA damage response. We present accumulating evidence that histone protein changes help relieve the chromatin barrier to DNA repair by regulating chromatin compaction and mobility. We also highlight how histone modifications and variants control transcriptional silencing at damage sites, and we describe both pre-existing and DNA damage-induced chromatin features that govern DNA damage signaling and guide DNA repair pathway choice. We discuss how histone dynamics ultimately participate to the restoration of epigenome integrity and present our current knowledge of key molecular players involved in these critical processes.

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Citations

Sep 17, 2020·International Journal of Molecular Sciences·Philippe Johann To Berens, Jean Molinier
Nov 11, 2020·Cells·Juliette FerrandSophie E Polo
Nov 4, 2020·Nutrients·Janusz BlasiakCezary Chojnacki
Mar 26, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Beatriz Maria Veloso PereiraKarina Thieme
Aug 21, 2021·DNA Repair·Pedro OrtegaAndrés Aguilera
Oct 9, 2021·Critical Reviews in Food Science and Nutrition·Şule Kocabas, Nevin Sanlier

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