PMID: 2125363Dec 1, 1990Paper

Control of the expression of a class II major histocompatibility gene (HLA-DR) in various human cell types: down-regulation by IL-1 but not by IL-6, prostaglandin E2, or glucocorticoids

Scandinavian Journal of Immunology
Y WatanabeA C Allison

Abstract

We have examined the effects of recombinant human IL-1 alpha and IL-1 beta on expression of the gene for the class II major histocompatibility antigen, HLA-DR, and the class I MHC antigen, HLA-B7, induced by natural or recombinant human IFN-gamma in several human cell types. Recombinant hIL-1 alpha and hIL-1 beta antagonized the class II MHC-inducing effect of IFN-gamma in human monocytes and normal skin fibroblasts, and in chondrosarcoma and astrocytoma cell lines. In the presence of IL-1 alpha or IL-1 beta, the induction by IFN-gamma of HLA-DR mRNA, and the expression of the corresponding antigen on the cell surface, were reduced when analysed by dot-blot hybridization and flow cytometry respectively. Nuclear transcription assays showed that IFN-gamma augmented expression of the HLA-DR gene and that IL-1 alpha inhibited this effect. IL-1-mediated inhibition was not observed with IFN-gamma-induced expression of MHC class I mRNA (HLA-B7). Both IL-1 alpha and IL-1 beta induced production of IL-6 mRNA and of PGE2 in these cell types. However, recombinant IL-6 or PGE2 did not inhibit IFN-gamma-induced HLA-DR mRNA expression. Dexamethasone did not inhibit HLA-DR expression in the cells studied but eliminated the inhibitory effect o...Continue Reading

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Citations

Jan 24, 1998·Journal of Dermatological Science·J GrabbeB M Henz
Jun 26, 2001·Journal of Clinical Periodontology·C Bisson-BoutelliezM C Bene
Jan 13, 2005·Critical Care Medicine·Sven K Tschoeke, Lyle L Moldawer
Apr 8, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·P HorínI Vinkler
Mar 19, 2004·American Journal of Respiratory and Critical Care Medicine·Yves Le TulzoBernard Drénou
Apr 2, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·A ChéronB Allaouchiche
Dec 1, 2007·Injury·Sven K Tschoeke, Wolfgang Ertel
Jun 18, 2017·Journal of the American Society of Nephrology : JASN·Dawn J CasterKenneth R McLeish

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