PMID: 18407193Mar 1, 1994Paper

Control of the preovulatory Luteinizing Hormone surge by Gonadotropin-Releasing Hormone antagonists: prospects for clinical application

Trends in Endocrinology and Metabolism : TEM
H M Fraser, P Bouchard

Abstract

The preovulatory LH surge of the primate menstrual cycle represents a number of positive influences, a major component of which is a direct action of estradiol on the anterior pituitary lobe. Whether the LH surge also requires a corresponding burst of GnRH release from the hypothalamus has been debated. After many years of investigation, there is now conclusive evidence that a midcycle GnRH surge does occur in the primate. This is supported by studies in women with normal ovulatory cycles that demonstrate that blockade of the GnRH receptor by potent GnRH antagonists administered within 1-2 days of the expected midcycle can delay the LH surge. The ability to prevent the positive feedback effects of estradiol by GnRH antagonists is being employed for the controlled induction of follicular development and ovulation in the treatment of infertility and in in vitro fertilization programs.

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·S S KakarJ D Neill
Jan 1, 1991·The Journal of Endocrinology·K B Smith, H M Fraser
Apr 1, 1991·The Journal of Clinical Endocrinology and Metabolism·L A MarshallS E Monroe
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology·E Frenk
Jan 1, 1992·Trends in Endocrinology and Metabolism : TEM·R L Barbieri
Sep 1, 1992·Trends in Endocrinology and Metabolism : TEM·K Gordon, G D Hodgen
Aug 1, 1993·Trends in Endocrinology and Metabolism : TEM·H M Fraser, S F Lunn

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Citations

Jan 10, 2002·Journal of Biosciences·U Natraj
Jul 17, 1998·Frontiers in Neuroendocrinology·N Chabbert BuffetP Bouchard
Sep 30, 2008·Arthritis and Rheumatism·Otto T H M LelieveldEllen van Weert
Mar 15, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S LiG S Berenson
Jul 28, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G S AndersenB L Heitmann
Mar 16, 2000·Drugs·P S GilliesC M Perry

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