PMID: 8613696Apr 1, 1996Paper

Control of the production of soluble interleukin-4 receptors: implications in immunoregulation

Journal of Leukocyte Biology
R Fernandez-BotranN E Street

Abstract

Soluble cytokine receptors (sCR) are generated in vivo through proteolytic cleavage of the membrane-bound receptors or by direct translation of mRNAs specifically encoding the soluble forms. Despite their widespread presence in biological fluids, the physiological role of endogenous sCR as immunoregulatory molecules is not yet well understood. In vivo, exogenous soluble interleukin-4 receptors (sIL-4R) have been shown to have both agonistic and antagonistic effects on IL-4 responses, depending on the relative concentration ratios of sIL-4R to IL-4. In an effort to elucidate the potential role of endogenous sIL-4R in the regulation of IL-4 responses, the mechanisms controlling the production of sIL-4R have been investigated. Although many cell types are able to constitutively produce low levels, production of sIL-4R is significantly up-regulated in vitro by T cell activation and IL-4. The ability of splenic cells to produce sIL-4R and the serum levels of sIL-4R have consistently been found to be increased during immune responses characterized by T cell activation and IL-4 secretion (Th2 responses). In agreement, clones of Th2, but not Th1, cells were found to significantly up-regulate sIL-4R production following antigenic stimul...Continue Reading

Citations

Jul 17, 1999·Critical Reviews in Clinical Laboratory Sciences·R Fernandez-Botran
Mar 9, 2012·International Archives of Allergy and Immunology·Jitka S HansenMartinus Lovik
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Marie K LindbergClaes Ohlsson
Nov 14, 1997·The Journal of Experimental Medicine·T SchulteA Gessner
Oct 13, 2009·Immunology Letters·Spencer W Stonier, Kimberly S Schluns

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