Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.

Science
Liyun SangJames M Roberts

Abstract

The mechanisms by which quiescent cells, including adult stem cells, preserve their ability to resume proliferation after weeks or even years of cell cycle arrest are not known. We report that reversibility is not a passive property of nondividing cells, because enforced cell cycle arrest for a period as brief as 4 days initiates spontaneous, premature, and irreversible senescence. Increased expression of the gene encoding the basic helix-loop-helix protein HES1 was required for quiescence to be reversible, because HES1 prevented both premature senescence and inappropriate differentiation in quiescent fibroblasts. In some human tumors, the HES1 pathway was activated, which allowed these cells to evade differentiation and irreversible cell cycle arrest. We conclude that HES1 safeguards against irreversible cell cycle exit both during normal cellular quiescence and pathologically in the setting of tumorigenesis.

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H ScrableC Sapienza
Sep 28, 1995·Nature·S JarriaultA Israel
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Jun 25, 1996·Biochemical and Biophysical Research Communications·D Grbavec, S Stifani
Mar 10, 2000·Science·T ChengD T Scadden
Aug 31, 2002·The Journal of Biological Chemistry·Young Hye KwonAngela L Tyner
Aug 13, 2003·The EMBO Journal·Christian M BeauséjourJudith Campisi
Jun 17, 2005·Cancer Research·Ileana C CuevasAnita Lal
Sep 2, 2005·British Journal of Cancer·O HopferS Aebi
Mar 1, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Sergei A GrigoryevEvgenya Y Popova
Mar 3, 2006·PLoS Biology·Hilary A CollerJames M Roberts
Mar 4, 2006·Stem Cells·Xiaobing YuCurt I Civin
May 30, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Christine L CurryKimberly E Foreman
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna

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Citations

Aug 7, 2012·Cancer Immunology, Immunotherapy : CII·Shijun KangRongcheng Luo
Aug 24, 2010·International Journal of Colorectal Disease·Heiying JinYijiang Ding
Apr 10, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christine W Hsu, Jordan M Symons
Feb 17, 2009·Biogerontology·Jan O Nehlin, Torben Barington
Feb 26, 2009·Journal of Mammary Gland Biology and Neoplasia·David C Harmes, James DiRenzo
Jan 6, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hei-Ying JinYijing Ding
Apr 30, 2013·Cancer Letters·Anja SchillertMartin R Sprick
Dec 24, 2011·Cell Death and Differentiation·C PaulE Fabbrizio
Jul 24, 2013·Nature Reviews. Molecular Cell Biology·Cosetta BertoliRobertus A M de Bruin
Mar 27, 2009·The Journal of Biological Chemistry·Cédric S TremblayMadeleine Carreau
Sep 12, 2013·Cellular Reprogramming·D N Wells
Aug 10, 2012·Molecular Biology of the Cell·Aster Legesse-MillerHilary A Coller
Oct 5, 2011·Human Molecular Genetics·Vilma BarrocaPierre Fouchet
Aug 22, 2013·Genes & Development·Ben MartynogaFrançois Guillemot
Oct 22, 2009·Pigment Cell & Melanoma Research·Liliana Ossowski, Julio A Aguirre-Ghiso
Nov 26, 2011·Science·Hilary A Coller
Aug 27, 2013·Doklady. Biochemistry and Biophysics·V S PyatenkoS G Andreev
Jun 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria Soledad SosaJulio A Aguirre-Ghiso
Sep 29, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian C BelyeaCorinne M Linardic
Nov 20, 2012·BMC Medicine·Rossella RotaFranco Locatelli
Nov 5, 2010·PLoS Biology·Johanna M S LemonsHilary A Coller
Sep 15, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yan-Yan XuYi-Jiang Ding
Jun 14, 2014·Science·Anoop P PatelBradley E Bernstein
Jun 7, 2014·Interface Focus·Guang Yao
Nov 27, 2014·Japanese Journal of Clinical Oncology·Hugh S ColvinHideshi Ishii
Sep 18, 2012·Experimental Cell Research·Caroline M WickramasinghePhilip H Jones
Jun 19, 2009·Kidney International·Peter M PriceJudit Megyesi
Sep 8, 2010·Biochimica Et Biophysica Acta·Maristella CoglievinaSándor Pongor
Feb 23, 2010·Blood Cells, Molecules & Diseases·Fanny L CasadoThomas A Gasiewicz

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