PMID: 45500Feb 1, 1978

Control of the uteroplacental circulation in health and disease

European Journal of Obstetrics, Gynecology, and Reproductive Biology


The various neurohumoral and intrinsic factors that control the uteroplacental hemodynamics in health and disease and in responses to physiologic and pharmacologic stimuli have been reviewed. The following conclusions may be derived: We still need improvement in our methodology of monitoring uterine blood flow. The present methods, which have some reliability, are not easily applicable to human subjects and even in animals their use presents problems of accuracy and sensitivity with which the investigator must become familiar. The marked and progressive increase in uterine blood flow that occurs during pregnancy is caused by complex factors, some of which are hormonal and hemodynamic in nature. The increased vascularity of the pregnant uterus and the opening of the arterioles during the process of formation of the intervillous space are important factors that facilitate the increase in uterine blood flow. The increment seems to be totally derived from the increment in the cardiac output that occurs during pregnancy. There seems to be no redistribution among the regional blood flows of the body. In the anesthetized condition the blood flow to the uterus depends largely on the perfusing pressure; the critical closing pressure see...Continue Reading


Apr 1, 1974·Endocrinology·R ResnikG Meschia
Mar 15, 1974·American Journal of Obstetrics and Gynecology·F C Greiss, S G Anderson
May 1, 1968·Circulation Research·N S ASSALI, J Kirschbaum TH Dilts PV
Jun 1, 1954·The American Journal of the Medical Sciences·L C CHESLEY
Nov 1, 1955·The Journal of Clinical Investigation·J METCALFEC S BURWELL
Mar 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·N S ASSALI, M ROSS
Apr 1, 1961·Physics in Medicine and Biology·D G WYATT


Sep 11, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ivo BrosensGiuseppe Benagiano
Jan 1, 1991·Critical Reviews in Toxicology·J Meier, K Stocker
Mar 1, 1985·Canadian Anaesthetists' Society Journal·J HeinonenO Takkunen

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