Control of transitions between locomotor-like and paw shake-like rhythms in a model of a multistable central pattern generator

Journal of Neurophysiology
Jessica ParkerGennady S Cymbalyuk

Abstract

The ability of the same neuronal circuit to control different motor functions is an actively debated concept. Previously, we showed in a model that a single multistable central pattern generator (CPG) could produce two different rhythmic motor patterns, slow and fast, corresponding to cat locomotion and paw shaking. A locomotor-like rhythm (~1 Hz) and a paw shake-like rhythm (~10 Hz) did coexist in our model, and, by applying a single pulse of current, we could switch the CPG from one regime to another (Bondy B, Klishko AN, Edwards DH, Prilutsky BI, Cymbalyuk G. In: Neuromechanical Modeling of Posture and Locomotion, 2016). Here we investigated the roles of slow intrinsic ionic currents in this multistability. The CPG is modeled as a half-center oscillator circuit comprising two reciprocally inhibitory neurons. Each neuron is equipped with two slow inward currents, a Na+ current ( INaS) and a Ca2+ current ( ICaS). ICaS inactivates much more slowly and at more hyperpolarized voltages than INaS. We demonstrate that INaS is the primary current driving the paw shake-like bursting. ICaS is crucial for the locomotor-like bursting, and it is inactivated during the paw shake-like activity. We investigate the sensitivity of the bursting...Continue Reading

References

Dec 1, 1991·Journal of Neurophysiology·K G Pearson, S Rossignol
Jan 1, 1984·Experimental Brain Research·J HounsgaardO Kiehn
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·W O Friesen
Jan 1, 1994·Biological cybernetics·G S CymbalyukR M Borisyuk
Jul 1, 1993·Journal of Neurophysiology·J R HuguenardD A Prince
Feb 1, 1996·Journal of Neurophysiology·G G TurrigianoL F Abbott
Jul 1, 1996·Physiological Reviews·E Marder, R L Calabrese
Jun 1, 1997·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·S R Soffe
May 3, 2000·The European Journal of Neuroscience·K P CarlinR M Brownstone
Jul 10, 2001·Journal of Computational Neuroscience·A A HillR L Calabrese
Aug 29, 2001·Journal of Computational Neuroscience·P J Hahn, D M Durand
Dec 1, 2001·Current Biology : CB·E Marder, D Bucher
Apr 16, 2002·The Journal of Comparative Neurology·Mathis Frøshaug StokkeOle Kiehn
Apr 27, 2002·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ari Berkowitz
Nov 15, 2002·Nature·Alexei V EgorovAngel A Alonso
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
Mar 4, 2003·Journal of Neurophysiology·Lorenzo Cangiano, Sten Grillner
Jun 5, 2003·Chaos·Robert J. Butera
Jun 20, 2003·Journal of Neurophysiology·Petronella KettunenAbdeljabbar El Manira
Oct 24, 2003·Journal of Neurophysiology·Nikolai I KononenkoF Edward Dudek
Dec 25, 2003·The Journal of Physiology·Julien HeringRégis C Lambert
Feb 10, 2004·IEEE Transactions on Bio-medical Engineering·Chuan LuoJohn H Byrne
Jun 11, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael SorensenRonald L Calabrese
Aug 28, 2004·Journal of Neurophysiology·Pablo FuentealbaMircea Steriade
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lorenzo Cangiano, Sten Grillner
Apr 1, 2005·Journal of Neurophysiology·S YakovenkoA Prochazka
Apr 15, 2005·Journal of Computational Neuroscience·Gennady Cymbalyuk, Andrey Shilnikov
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrey ShilnikovGennady Cymbalyuk
Sep 8, 2006·Journal of Neurophysiology·David PaydarfarJohn R Clay
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Flavio Fröhlich, Maxim Bazhenov

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Citations

Jul 3, 2021·International Journal of Molecular Sciences·Jessica AusbornSimon M Danner
Dec 29, 2021·PLoS Computational Biology·Jessica R ParkerGennady S Cymbalyuk

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