PMID: 6159628Jul 1, 1980Paper

Control of tumor growth in animals by infusion of an angiogenesis inhibitor

Proceedings of the National Academy of Sciences of the United States of America
R LangerJ Folkman

Abstract

Angiogenesis and tumor growth were inhibited in two different animal models by regional infusion of a partially purified cartilage extract. In rabbits bearing corneal implants of V2 carcinoma and receiving the inhibitor, vascular growth rates were < 3% of those in control animals receiving either Ringer's solution or bovine trypsin inhibitor (Trasylol). Subconjunctival B16 melanoma implants in mice receiving the inhibitor weight < 2.5% of implants in mice receiving Ringer's solution, Trasylol, or albumin. Histologic study of major organs and standard blood tests revealed no toxic effects in any of the animals. The inhibitor did not retard the growth of either tumor cell type in tissue culture at concentrations as high as 1 mg/ml. These results suggest that the cartilage factor does not interfere with the growth of the tumor cell population directly but that it prevents tumor growth by inhibiting angiogenesis.

References

Jun 1, 1978·Ophthalmology·A PatzJ Gardner
Feb 1, 1975·The Journal of Experimental Medicine·H Brem, J Folkman
May 1, 1976·Scientific American·J Folkman
Oct 1, 1973·The Journal of Experimental Medicine·J Folkman, M Hochberg
Aug 1, 1972·The Journal of Experimental Medicine·M A GimbroneJ Folkman

❮ Previous
Next ❯

Citations

Jan 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R S Kerbel
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Takayuki FurumatsuYoshifumi Ninomiya
Nov 1, 1991·Journal of Cellular Biochemistry·M A Moses, R Langer
Nov 1, 1993·Journal of Cellular Physiology·A N MurphyW G Stetler-Stevenson
Jan 1, 1982·Cancer Metastasis Reviews·E F WheelockG A Truitt
May 1, 1995·Bulletin of Mathematical Biology·H M Byrne, M A Chaplain
Jan 1, 1993·International Journal of Clinical & Laboratory Research·D RibattiL Roncali
Feb 1, 1983·Applied Biochemistry and Biotechnology·R Langer, J Murray
Aug 1, 1983·Biological Trace Element Research·M M Jacobs
Feb 6, 2008·Angiogenesis·Domenico Ribatti
Jan 1, 2012·Journal of Ocular Biology, Diseases, and Informatics·Arti SinghAshok Patel
Sep 1, 1994·Pharmacology & Therapeutics·W Auerbach, R Auerbach
Nov 1, 1990·Trends in Pharmacological Sciences·T E Maione, R J Sharpe
Jun 8, 2002·Survey of Ophthalmology·Tina T L WongPeng T Khaw
Jan 29, 1983·Lancet
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·L M WeinJ T Wu
Feb 1, 1998·Trends in Cardiovascular Medicine·B B MooreR M Strieter
Jul 18, 2008·Nature Reviews. Cancer·Bruce R Zetter
Jul 20, 2007·Leukemia·D Ribatti
Oct 8, 1981·The New England Journal of Medicine·P M Gullino
Sep 1, 1987·Annals of Surgery·J Folkman, D E Ingber
Sep 6, 1994·Annals of the New York Academy of Sciences·E P SiposH Brem
Dec 23, 2011·Science Translational Medicine·Yihai CaoRobert Langer
Jun 1, 1988·Journal of Neurosurgery·C L FarrellR F Del Maestro
Aug 14, 2001·Biochemical and Biophysical Research Communications·B E PfisterT M Schmid
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M A MosesR Langer
Jun 9, 2000·The British Journal of Radiology·G M MorrisJ W Hopewell
Dec 29, 1983·Biochimica Et Biophysica Acta·D E Mullins, S T Rohrlich
Aug 31, 1981·Biochimica Et Biophysica Acta·I R Hart, I J Fidler
Oct 1, 1984·Journal of Medical Systems·W Düchting, T Vogelsaenger
Feb 28, 1983·Documenta Ophthalmologica. Advances in Ophthalmology·W A Manschot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.