Control strategies in systemic metabolism.

Nature Metabolism
Jessica Ye, Ruslan Medzhitov

Abstract

Metabolic control systems coordinate myriad processes across the cellular, tissue and organismal levels to optimize the allocation of limited supplies across multiple, often competing, metabolic demands. As such, the regulation of metabolism can be analysed from the perspective of the economic theory of supply and demand. Here, we discuss how such analyses can provide new insights into the logic of metabolic control. In particular, we suggest that, in addition to being subject to well-appreciated homeostatic control, metabolism is subject to supply-driven and demand-driven controls, each operated by a dedicated set of signals throughout various physiological states, including inflammation. Furthermore, we argue that systemic homeostasis is a derived feature that evolved from the control systems that monitor metabolic supply and demand.

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Citations

Feb 19, 2021·IScience·Hanne-Line RabbenChun-Mei Zhao
Apr 27, 2021·American Journal of Physiology. Endocrinology and Metabolism·K M O'ConnorF B McDonald
Sep 16, 2021·Journal of Cachexia, Sarcopenia and Muscle·Ayoung KimSang Geon Kim

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