Control systems and decision making for antibody production.

Nature Immunology
Christopher C GoodnowRobert Brink

Abstract

This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor (BCR) affinity for foreign antigen versus negative selection of BCR affinity for self antigen in germinal center B cells; and (4) survival versus death of antibody-secreting plasma cells. Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency.

References

Jan 1, 1975·Transplantation Reviews·G Möller
Sep 11, 1970·Science·P Bretscher, M Cohn
Jan 1, 1994·Annual Review of Immunology·M Z Radic, M Weigert
Apr 1, 1997·Immunological Reviews·R M SteinmanK Inaba
Aug 3, 1999·The Journal of Experimental Medicine·Y TakahashiG Kelsoe
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti
Nov 11, 1999·European Journal of Immunology·C García De VinuesaI C MacLennan
Sep 20, 2000·The Journal of Experimental Medicine·D M SzeI C MacLennan
Jul 4, 2001·The Journal of Experimental Medicine·D C HargreavesJ G Cyster
Sep 6, 2001·European Journal of Immunology·G CasseseR A Manz
Jan 29, 2002·Nature Immunology·Stephen W Martin, Christopher C Goodnow
May 22, 2002·Nature Immunology·Tien-An Yang ShihMichel C Nussenzweig
Jul 20, 2002·Science·Klaus OkkenhaugBart Vanhaesebroeck
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja E HauserRudolf A Manz
Sep 18, 2002·The Journal of Experimental Medicine·Elizabeth ClaytonMartin Turner
Oct 22, 2002·Nature Immunology·Patrick S CostelloDoreen A Cantrell
Nov 26, 2002·Science·Katsutoshi OzakiWarren J Leonard
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stuart G TangyePhilip D Hodgkin
Jan 17, 2003·Nature·Shane CrottyRafi Ahmed
Feb 4, 2003·Nature Immunology·Amy N AnzelonRobert C Rickert
Jul 9, 2003·Immunological Reviews·Ian C M MacLennanCarola G Vinuesa
Jul 17, 2003·The Journal of Clinical Investigation·Danielle T AveryStuart G Tangye
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giuliana CasseseRudolf A Manz
Jun 19, 1959·Science·J LEDERBERG

❮ Previous
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Citations

Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·Mini Bharathan, Isis K Mullarky
Jun 18, 2011·Analytical Chemistry·Zewen WeiZhihong Li
Oct 23, 2013·Immunology and Cell Biology·André Ballesteros-Tato, Troy D Randall
Jan 21, 2012·Nature Immunology·Stuart G Tangye, Robert Brink
Nov 17, 2010·Nature Immunology·Masaki Hikada, Moncef Zouali
Jun 8, 2012·Nature Medicine·Zheng Liu, Anne Davidson
Jun 26, 2012·Nature Reviews. Immunology·Zhenming XuPaolo Casali
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Johannes F ScheidHedda Wardemann
Jul 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Carrie N ArnoldBruce Beutler
Jul 4, 2012·The Journal of Experimental Medicine·Cindy S MaStuart G Tangye
Jul 10, 2013·The Journal of Experimental Medicine·André Ballesteros-TatoTroy D Randall
Apr 19, 2011·AIDS Research and Human Retroviruses·Per Johan KlasseJohn P Moore
Jun 2, 2012·Science·Oliver M Bannard, Jason G Cyster
Aug 17, 2012·Journal of Virology·Corin L DorfmeierJames P McGettigan
Jan 11, 2013·Arthritis Research & Therapy·Natalia V GiltiayEdward A Clark
Jan 11, 2013·Arthritis Research & Therapy·Alexis Boneparth, Anne Davidson
Nov 21, 2012·PloS One·Agapitos PatakasPaul Garside
Mar 28, 2013·PloS One·Il-Young HwangJohn H Kehrl
Jul 11, 2013·PloS One·Joshua A WeinsteinStephen R Quake
Jul 1, 2014·Nature Communications·Yan-Feng LiKong-Peng Lam
Mar 19, 2014·Nature Communications·Beatriz LeónAndré Ballesteros-Tato
Mar 29, 2014·Sensors·Simin MehrabaniAndrea M Armani
May 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Zahra SabouriChristopher C Goodnow
May 7, 2014·Immunology and Cell Biology·Hussein GhamlouchBrigitte Gubler
Oct 21, 2014·Influenza Research and Treatment·Cassandra M BerryMark Y Sangster
Sep 17, 2014·The Journal of Experimental Medicine·Emilie JacqueSteven C Ley
Jan 12, 2011·Annual Review of Immunology·Jennifer L CannonsPamela L Schwartzberg
Jan 7, 2014·Journal of Critical Care·Raquel AlmansaJesús F Bermejo-Martin
Feb 20, 2013·The Journal of Experimental Medicine·Yang ZhangKai-Michael Toellner
Feb 20, 2014·Current Opinion in Immunology·Roberta Pelanda
Sep 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Emilie E Vomhof-DeKreyElizabeth A Leadbetter
May 9, 2012·Seminars in Immunology·Igor KogutJohn C Cambier
May 19, 2012·Trends in Immunology·Dimitra Zotos, David M Tarlinton
Feb 22, 2012·Journal of Autoimmunity·Stefano SammicheliBence Rethi
Feb 15, 2012·Immunology Letters·Jean L Scholz, Michael P Cancro

❮ Previous
Next ❯

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