Controllable Mn-doped ZnO nanorods for direct assembly of a photoelectrochemical aptasensor

The Analyst
Jing LiHongbo Li

Abstract

A label-free photoelectrochemical (PEC) aptasensor for K(+) was first constructed by direct self-assembly of the K(+) aptamer onto the electrodeposited Mn-doped ZnO nanorods. In the presence of K(+), the conformation of G-quadruplex changes to a K(+)-stabilized conformation, which can efficiently prevent the quercetin electron donor from reaching the functionalized photoanode, thus proportionately affecting the quercetin-enhanced photocurrent response. Under the optimal experimental conditions, the fabricated biosensor exhibited a linear response in the K(+) concentration range of 0.012 to 12.32 nmol L(-1), with a detection limit of 4.0 pmol L(-1), which was 3-5 orders of magnitude lower than that of most of the recently reported methods. The presence of other ions did not interfere with the detection of K(+), and the results in serum samples agreed well with those obtained by ICP-MS. Using K(+) as the detection model, this novel PEC aptasensor exhibited a good performance in terms of ultrasensitivity, selectivity and simplicity, and it was economical. As regards the electrode modification, this work provided a convenient direct self-assembly strategy that did not require the use of ionic polymers such as PDDA as a binder. Thus...Continue Reading

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Citations

Jan 27, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Chunli SunFan Xia

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