PMID: 15348496Sep 7, 2004Paper

Controllable porosity hydroxyapatite ceramics as spine cage: fabrication and properties evaluation

Journal of Materials Science. Materials in Medicine
W W LuJ C Y Leong

Abstract

A procedure was designed to prepare porosity-graded hydroxyapatite (HA) ceramics simulating the bimodal structure of natural bone, which could be used to build a cage that would promote the reconstruction of the anterior column after vertebrectomy or corpectomy in tumor and trauma surgery. HA ceramics with controllable pore size distribution and porosity were developed by using chitosan and Poly(vinyl alcohol) (PVA) as the pore-forming agents. HA ceramics with worthwhile properties such as a wide range of volume porosity (10-50%) and pore size (nanometer to 400 microm) can be obtained from this method, which allows the fabrication of HA ceramics with desirable porous characteristics simulating the bimodal natural bone architecture expected to provide advantages for bony fusion in the intervertebral foramina. When coated with chitosan-gelatin network, the bending strength of the porous HA ceramics significantly improved. The polymer network coated porous HA have potential application in the construction of cages for spinal operations.

Citations

Nov 21, 2008·Journal of Materials Science. Materials in Medicine·Chiara Vitale-BrovaroneEnrica Verné
Aug 17, 2010·Journal of Materials Science. Materials in Medicine·Hui ChenYumin Yang
Apr 23, 2008·Journal of the Royal Society, Interface·Anushini MuthutantriMohan Edirisinghe
Jan 16, 2007·Journal of Materials Science. Materials in Medicine·Hong ZhuangKang De Yao
Dec 9, 2009·Biomaterials·Sergey V Dorozhkin
Jan 1, 2010·Journal of Functional Biomaterials·Sergey V Dorozhkin
Feb 1, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Takashi KaitoAkira Myoui
Mar 14, 2013·Expert Review of Medical Devices·Ioannis D PapanastassiouFrank D Vrionis
Sep 6, 2013·Materials·Sergey V Dorozhkin

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