Controllable release of nitric oxide and doxorubicin from engineered nanospheres for synergistic tumor therapy

Acta Biomaterialia
Lianjiang TanYu-Mei Shen

Abstract

NaYF4:Yb,Er upconversion nanoparticles (UCNPs) capped with long-chain carboxylic acid were synthesized and then conjugated with chitosan (CS) in the aid of N-hydroxysuccinimide. The resultant nanocompound was integrated with doxorubicin (DOX) and Roussin's black salt (RBS), a photosensitive nitric oxide (NO) donor to produce stimuli-responsive UCNPs(DOX)@CS-RBS nanospheres as nanocarriers for controllable drug delivery. On the one hand, the encapsulated UCNPs can efficiently absorb NIR photons and convert them into visible photons to trigger NO release. On the other hand, the entrapped DOX can be released at lowered pH from the swollen nanospheres caused by stretched oleoyl-CS chains under acidic conditions. The UCNPs(DOX)@CS-RBS nanospheres exhibit great therapeutic efficacy, which is attributable to the combination of NO and DOX releases based on NO dose-dependent mechanisms. This study highlights the controllable release of NO and DOX from the same nanocarriers and the synergistic therapeutic effect on tumors, which could give new insights into improving cancer nanotherapeutics. In this paper, core-shell structured UCNPs(DOX)@CS-RBS nanospheres have been designed and synthesized via a step-by-step procedure. The stimuli-resp...Continue Reading

Citations

Jan 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuan ZhangYulei Chang
Oct 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianghua LiGuangli Yu
Jan 27, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jin WangYong Yao
Dec 20, 2020·Colloids and Surfaces. B, Biointerfaces·Lianjiang Tan, Changyu He
May 18, 2021·Bioactive Materials·Xiaohua ZhengHaijun Yu
Jan 19, 2021·ACS Biomaterials Science & Engineering·Chaoqun YouFei Wang

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