Controlled antibiotic-releasing Antheraea assama silk fibroin suture for infection prevention and fast wound healing

Surgery
Arup Jyoti ChoudhuryKasturi Kalita

Abstract

The quest for developing silk fibroin as a biomaterial for drug release systems continues to draw research interest owing to its impressive mechanical properties as well as biocompatibility and biodegradability. The aim of this study is to develop low-temperature O2 plasma-treated muga (Antheraea assama) silk fibroin (AASF) yarn impregnated with amoxicillin trihydrate as controlled antibiotic-releasing suture (AASF/O2/AMOX) for preventing postoperative site bacterial infection and fast wound healing. In this experimental study, AASF and AASF/O2/AMOX sutures are used to close the surgical wounds of adult male Wistar rats of 4 months old and weighing 200-230 g. Surface hydrophilicity induced by O2 plasma results in an increase in drug-impregnation efficiency of AASF/O2 yarn by 16.7%. In vitro drug release profiles show continuous and prolonged release of AMOX from AASF/O2/AMOX yarn up to 336 hours. In vitro hemolysis assay reveals that O2 plasma treatment and subsequent impregnation of AMOX do not affect the heertetmocompatibility of AASF yarn. The AASF/O2/AMOX yarn proves to be effective for in vitro growth inhibition of Staphylococcus aureus and Escherichia coli, whereas AASF offers no antibacterial activity against both types ...Continue Reading

References

Jan 17, 2002·Biomaterials·Jai Paul Singhal, Alok R Ray
Nov 9, 2002·Biomaterials·Gregory H AltmanDavid L Kaplan
May 24, 2011·American Journal of Surgery·Ibrahim Galal, Khaled El-Hindawy
Jun 19, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·David A SanchezAdam J Friedman
Jul 31, 2013·American Journal of Infection Control·Guo-qing LiWen Zhou
Aug 16, 2014·International Wound Journal·Peralam Y Prakash
Dec 24, 2014·Urologia·Gabriele Sganga

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Citations

Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Raghuram KandimallaJibon Kotoky
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Arup Jyoti ChoudhuryJoyanti Chutia
Feb 17, 2019·Journal of Biomedical Materials Research. Part a·Rebecca M HaleyHorst A von Recum
Aug 11, 2021·Polymers·Alena Opálková ŠiškováAnita Eckstein Andicsová
Jun 10, 2019·ACS Biomaterials Science & Engineering·Pui Fai NgBin Fei

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