Controlled Chemical Derivatisation of Carbon Nanotubes with Imaging, Targeting, and Therapeutic Capabilities

Chemistry : a European Journal
Cécilia Ménard-MoyonAlberto Bianco

Abstract

In drug delivery, carbon nanotubes (CNTs) hold a great potential as carriers because of their ability to easily cross biological barriers and be internalised into cells. Their high aspect ratio allows multi-functionalisation and their development as a multimodal platform for targeted therapy. In this article, we report the controlled covalent derivatisation of triple-functionalised CNTs with the anticancer drug gemcitabine, folic acid as a targeting ligand and fluorescein as a probe. The anticancer activity of gemcitabine was maintained after covalent grafting onto the CNTs. The functionalised nanotubes were internalised into both folate-positive and negative cells, suggesting the passive diffusion of CNTs. Overall, our approach is versatile and offers a precise chemical control of the sidewall functionalisation of CNTs and the possibility to manoeuvre the types of functionalities required on the nanotubes for a multimodal therapeutic strategy.

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Citations

Jan 16, 2016·Therapeutic Delivery·Marta Roldo
Nov 19, 2015·Chemistry : a European Journal·Marco FrasconiSilvia Giordani
Nov 3, 2016·Nanoscale·Bhimareddy DineshCécilia Ménard-Moyon
Feb 14, 2017·Journal of the American Chemical Society·Mahdi KarimiMichael R Hamblin
May 12, 2020·Physical Chemistry Chemical Physics : PCCP·A Ansón-CasaosW K Maser
Apr 22, 2020·Angewandte Chemie·Matteo Andrea LucherelliAlberto Bianco

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