PMID: 6113353Jun 27, 1981Paper

Controlled clinical trial of intravenous acyclovir in heart-transplant patients with mucocutaneous herpes simplex infections

Lancet
S ChouT C Merigan

Abstract

Viral cultures of mucocutaneous herpes simplex lesions became negative in 5 heart-transplant patients given a 7-day course of intravenous acyclovir. Relief of pain and healing of lesions paralleled the virological response. Similar clinical and virological responses were not seen in the 5 placebo-treated patients in this double-blind placebo-controlled trial. No adverse reactions attributable to acyclovir were noted. Shedding of herpes simplex viruses recurred in 3 patients after acyclovir therapy.

References

Jun 16, 1977·The New England Journal of Medicine·K H RandT C Merigan
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G B ElionH J Schaeffer

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Citations

Apr 1, 1984·European Journal of Clinical Microbiology·E de Clercq
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Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R A Zuckerman, A P Limaye
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Mar 1, 1992·Journal of Clinical Microbiology·M S FormanP Charache
Jul 20, 1982·The American Journal of Medicine·O L LaskinP S Lietman

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