PMID: 8588056Jul 1, 1995Paper

Controlled comparison of the effects and abrupt discontinuation of buspirone and lorazepam

Progress in Neuro-psychopharmacology & Biological Psychiatry
M Bourin, M Malinge

Abstract

1. The purpose of this study was to compare the effects and abrupt discontinuation of buspirone 15 or 20 mg tid and lorazepam 3 or 4 mg tid following 8 weeks of treatment. A total of 43 outpatients with generalized anxiety disorder were included in the study and 39 entered the withdrawal phase. 2. Clinical assessments were performed at baseline, 2, 4, 6 and 8 weeks (active phase) and after 9 and 10 weeks (withdrawal phase). These included the Hamilton anxiety scale, the visual analogue scale, the CHESS 84 (a check list for the evaluation of somatic symptoms) and the Lader tranquilizer withdrawal scale (translated in french). 3. Results show similar efficacy for lorazepam and buspirone during the active phase with a higher significant difference for buspirone on the CHESS 84 in relation with neurovegetatives symptoms: lorazepam D0 :16.30 +/- 3.14 D56: 5.10 +/- 0.93 (p < or = 0.01) buspirone D0 :18.82 +/- 3.4 D56: 4.73 +/- 1.18 (p < or = 0.001) No withdrawal phenomena was observed for both drugs using HAM-A lorazepam D63 :12.59 +/- 2.26 D70: 12.0 +/- 1.75 (p = ns) buspirone D63 :10.05 +/- 1.28 D70: 10.32 +/- 1.82 (p = ns) and the same significant difference using Lader scale: lorazepam D63 :4.44 +/- 0.89 D70: 6.96 +/- 1.28 (p < o...Continue Reading

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Citations

Aug 17, 2011·Therapeutics and Clinical Risk Management·Patrick LemoineNava Zisapel
Jun 22, 2007·Pharmacology & Therapeutics·Agnieszka Palucha, Andrzej Pilc
Aug 25, 2012·International Journal of Psychiatry in Clinical Practice·Michael LindenHans-Ulrich Wittchen
Oct 31, 2002·Human Psychopharmacology·Johan A. Den BoerBernhard R. Slaap
Jul 21, 2006·The Cochrane Database of Systematic Reviews·C A ChessickJ J S S dos Santos Souza
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Patrik RoserWolfram Kawohl

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