Controlled cortical impact in swine: pathophysiology and biomechanics

Journal of Neurotrauma
Geoffrey T ManleyS Scott Panter

Abstract

Investigations of the basic pathological, cellular, and molecular mechanisms of traumatic brain injury (TBI) over the past two decades have been carried out primarily in rodents. Unfortunately, these studies have not translated into improved outcome in patients with TBI. To better model human TBI, a swine model of controlled cortical impact (CCI) was developed. A CCI device was used to generate a focal lesion in 23 anesthetized male Yorkshire swine. In 10 swine, CCI parameters of velocity and dwell time were varied to achieve a consistent injury (3.5 m/sec, 400 msec, respectively). In 13 swine, depth of depression was varied from 9 to 12 mm. Physiological data, including heart rate (HR), mean arterial blood pressure (MAP), intracranial pressure (ICP), and cerebral perfusion pressure (CPP), were collected for 10 h after injury. Following injury, ICP and HR increased above baseline values in all swine, with a more pronounced elevation in animals impacted to a depth of depression of 12 mm. An 11-mm depth of depression was found to most closely mimic pathological features of human TBI with edema, infiltration of inflammatory cells, pericapillary hemorrhage, and petechial hemorrhages in the white matter. Injury to a depth of depress...Continue Reading

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Citations

Sep 6, 2008·Journal of Neurotrauma·Ralph Timaru-KastBeat Alessandri
Jul 17, 2008·Journal of Neurotrauma·Kathryn E SaatmanUNKNOWN Workshop Scientific Team and Advisory Panel Members
Feb 22, 2011·Journal of Neurotrauma·Atsuhiro NakagawaTeiji Tominaga
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