Controlled Delivery of a Focal Adhesion Kinase Inhibitor Results in Accelerated Wound Closure with Decreased Scar Formation

The Journal of Investigative Dermatology
Kun MaGeoffrey C Gurtner

Abstract

Formation of scars after wounding or trauma represents a significant health care burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, because of the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries. To address this issue, we have developed a pullulan collagen-based hydrogel to deliver FAKI to excisional and burn wounds in mice. Specifically, two distinct drug-laden hydrogels were developed for rapid or sustained release of FAKI for treatment of burn wounds and excisional wounds, respectively. Controlled delivery of FAKI via pullulan collagen hydrogels accelerated wound healing and reduced collagen deposition and activation of scar-forming myofibroblasts in both wound healing models. Our study highlights a biomaterial-based drug delivery ap...Continue Reading

Citations

Aug 9, 2020·Experimental Dermatology·Abigail De La PenaChelsey S Simmons
May 15, 2020·Journal of Clinical Medicine·Britta KuehlmannGeoffrey C Gurtner
Aug 28, 2020·Frontiers in Physiology·Sun Hyung KwonGeoffrey C Gurtner
Dec 12, 2020·Biomaterials·Abbas ShafieeDietmar W Hutmacher
Jan 19, 2019·Journal of Dermatological Science·Mai KanemaruNorito Katoh
May 21, 2021·Frontiers in Bioengineering and Biotechnology·Dharshan SivarajGeoffrey C Gurtner
Jul 17, 2021·International Journal of Biological Macromolecules·Murugan Prasathkumar, Subramaniam Sadhasivam
Jul 20, 2021·Advances in Wound Care·Kellen ChenGeoffrey C Gurtner
Sep 2, 2021·Advances in Wound Care·Shamik MascharakMichael T Longaker
Sep 8, 2021·Nature Communications·Kellen ChenGeoffrey C Gurtner
Sep 22, 2021·Advances in Wound Care·Artem A TrotsyukGeoffrey C Gurtner

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