Controlled delivery of antigens and adjuvants in vaccine development

Journal of Pharmaceutical Sciences
Z Zhao, K W Leong

Abstract

Advances in the understanding of the pathogenesis of infectious diseases and cancer immunology have inspired many new approaches to vaccine development. Many subunit antigens and peptides that are effective for vaccination have been discovered. These subunit antigens in tum stimulate synthesis of effective adjuvants to enhance their immunogenicity. Controlled-release technology offers the potential of further improving the efficacy of conventional vaccine formulations by optimizing the temporal and spatial presentation of the-antigens and adjuvants to the immune system. The combination of sustained release and depot effect may also reduce the amount of antigens or adjuvants needed and eliminate the booster shots that are necessary for the success of many vaccinations. This review examines the contribution controlled release technology can make in various areas of vaccination, with an emphasis on tumor vaccines.

References

Jan 1, 1979·Journal of Immunological Methods·I Preis, R S Langer
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H J StaussC Sinclair
Feb 1, 1992·Research in Immunology·C R AlvingN M Wassef
Jun 24, 1991·Journal of Immunological Methods·C R Alving
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L F FriesC R Alving
Feb 20, 1991·International Journal of Cancer. Journal International Du Cancer·J Vaage, E Mayhew
Mar 1, 1991·Molecular Immunology·J H EldridgeR M Gilley
Mar 1, 1990·Immunology Today·G Gregoriadis
Nov 7, 1990·Journal of the National Cancer Institute·J TreatA Rahman
May 1, 1989·Pharmaceutical Research·Y Tabata, Y Ikada
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y WatanabeT Sakata
Sep 1, 1987·The Journal of Pharmacy and Pharmacology·Y Tabata, Y Ikada
May 1, 1969·The Journal of Clinical Investigation·R I WeedE W Merrill
Nov 15, 1974·Nature·A G Allison, G Gregoriadis
Dec 1, 1984·Journal of Medical Microbiology·M V Pimm, R W Baldwin
Aug 1, 1995·AIDS Research and Human Retroviruses·L B LachmanJ L Cleland

❮ Previous
Next ❯

Citations

Jul 1, 2011·Immunologic Research·Pawel KalinskiDavid L Bartlett
Jan 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shaobing ZhouHeming Li
Oct 5, 2002·Advanced Drug Delivery Reviews·Shari Lofthouse
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R A JainN H Shah
Nov 20, 2004·Immunology and Cell Biology·S A MoschosH O Alpar
Jun 1, 2002·BMJ : British Medical Journal·Gregory A PolandRuben Bonilla-Guerrero
Feb 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takami AkagiMitsuru Akashi
Jan 7, 1999·Drug Development and Industrial Pharmacy·R JainC T Rhodes
Dec 5, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Saravanakumar ArthanariHyun Tae Jang
Nov 15, 2008·Journal of Pharmaceutical Sciences·Mohamed A Shaker, Husam M Younes
Jul 17, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sarah GordonSarah Hook
Mar 11, 2009·Advanced Drug Delivery Reviews·Yogita Krishnamachari, Aliasger K Salem
Nov 27, 2007·Vaccine·David A ZaharoffJohn W Greiner
Feb 24, 2007·International Journal of Pharmaceutics·M HamidiS Mohammadi-Samani
Mar 20, 2015·Biotechnology and Bioengineering·Ferry P W MelchelsDietmar W Hutmacher
Apr 4, 2015·Human Vaccines & Immunotherapeutics·Chi-Ying LinMing-Kung Yeh
Jan 29, 2011·International Journal of Pharmaceutics·Thunjiradasiree KojarunchittStefania Baldursdottir
Jul 10, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sakulrat RattanakiatYoshinobu Takakura
Dec 8, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Thunjiradasiree KojarunchittSarah Hook
Nov 9, 2016·Acta Biomaterialia·Carina PeresHelena F Florindo
Jul 5, 2001·Home Health Care Services Quarterly·E M ZelinskiUNKNOWN Long Beach Longitudinal Study
Sep 16, 2004·Journal of Biomedical Materials Research. Part a·Mutsumi Yoshida, Julia E Babensee
Sep 15, 2005·Journal of Biomedical Materials Research. Part a·Julia E Babensee, Abhijit Paranjpe
Dec 5, 2003·Science and Engineering Ethics·Johannes J Schroots
May 14, 2009·Expert Review of Molecular Diagnostics·Jian-Ming LüChangyi Chen
Oct 14, 2014·Expert Review of Vaccines·Samantha L KurtzDavid A Zaharoff
May 22, 2018·Frontiers in Immunology·Flávia CastroMaria José Oliveira
Feb 11, 2021·Biologicals : Journal of the International Association of Biological Standardization·Asma Hamzaoui, Fatima Laraba-Djebari
May 10, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica C JoyceMark R Prausnitz
Jan 10, 2002·Journal of Pharmaceutical Sciences·Husam M Younes, Brian G Amsden
May 2, 2002·Journal of the American Chemical Society·Mercedes DelgadoKim D Janda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.