Controlled exposure study of air pollution and T-wave alternans in volunteers without cardiovascular disease.

Environmental Health Perspectives
Marjan KushaKumaraswamy Nanthakumar

Abstract

Epidemiological studies have assessed T-wave alternans (TWA) as a possible mechanism of cardiac arrhythmias related to air pollution in high-risk subjects and have reported associations with increased TWA magnitude. In this controlled human exposure study, we assessed the impact of exposure to concentrated ambient particulate matter (CAP) and ozone (O3) on T-wave alternans in resting volunteers without preexisting cardiovascular disease. Seventeen participants without preexisting cardiovascular disease were randomized to filtered air (FA), CAP (150 μg/m3), O3 (120 ppb), or combined CAP + O3 exposures for 2 hr. Continuous electrocardiograms (ECGs) were recorded at rest and T-wave alternans (TWA) was computed by modified moving average analysis with QRS alignment for the artifact-free intervals of 20 beats along the V2 and V5 leads. Exposure-induced changes in the highest TWA magnitude (TWAMax) were estimated for the first and last 5 min of each exposure (TWAMax_Early and TWAMax_Late respectively). ΔTWAMax (Late-Early) were compared among exposure groups using analysis of variance. Mean ± SD values for ΔTWAMax were -2.1 ± 0.4, -2.7 ± 1.1, -1.9 ± 1.5, and -1.2 ± 1.5 in FA, CAP, O3, and CAP + O3 exposure groups, respectively. No si...Continue Reading

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Citations

Oct 26, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew J Campen
Dec 12, 2012·The Canadian Journal of Cardiology·Alex WatkinsKumaraswamy Nanthakumar
Sep 27, 2014·Critical Reviews in Toxicology·Julie E GoodmanFerdinand J Venditti
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May 8, 2013·Circulation·Diane R Gold, Murray A Mittleman
Mar 20, 2018·Current Opinion in Physiology·Vineeta TanwarLoren E Wold

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Software Mentioned

MATLAB
SAS
TWA

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