Controlled hierarchical self-assembly of networked coordination nanocapsules via the use of molecular chaperones.

Chemical Science
Xiangquan HuJerry L Atwood

Abstract

Supramolecular chaperones play an important role in directing the assembly of multiple protein subunits and redox-active metal ions into precise, complex and functional quaternary structures. Here we report that hydroxyl tailed C-alkylpyrogallol[4]arene ligands and redox-active MnII ions, with the assistance of proline chaperone molecules, can assemble into two-dimensional (2D) and/or three-dimensional (3D) networked nanocapsules. Dimensionality is controlled by coordination between the exterior of nanocapsule subunits, and endohedral functionalization within the 2D system is achieved via chaperone guest encapsulation. The tailoring of surface properties of nanocapsules via coordination chemistry is also shown as an effective method for the fine-tuning magnetic properties, and electrochemical and spectroscopic studies support that the nanocapsule is an effective homogeneous water-oxidation electrocatalyst, operating at pH 6.07 with an exceptionally low overpotential of 368 mV.

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Citations

Feb 11, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Johannes KargesSeth M Cohen
Jul 31, 2021·Accounts of Chemical Research·Li ShaoJerry L Atwood

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Methods Mentioned

BETA
protein subunit folding
scanning electron microscopy
X-ray
differential scanning calorimetry
dynamic light scattering

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